HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: S10A4 (P26447)
Protein S100-A4 (Calvasculin) (Metastasin) (Placental calcium-binding protein) (Protein Mts1) (S100 calcium-binding protein A4)
Gene: S100A4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.699

Property	Details
Experiments	25402006, 24658140, 30083275, unassigned2173
Identification Methods	two hybrid, protein complementation assay, affinity chromatography technology, cross-linking study, surface plasmon resonance, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005615 - extracellular space GO:0005634 - nucleus GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 101
+	Hs
		338660 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HORN_HUMAN (1-96): 6.3e-33: 121: 25.74
+	Hs
		338011 EGFR_HUMAN (1-1210): 0: 1241: 100.00		S10AB_HUMAN (2-97): 2.99e-36: 120: 27.84
+	Hs
		338220 EGFR_HUMAN (1-1210): 0: 1241: 100.00		S10AA_HUMAN (1-100): 4.52e-32: 109: 34.00
+	Hs
		337773 EGFR_HUMAN (1-1210): 0: 1241: 100.00		S10A9_HUMAN (3-91): 3.65e-28: 99.9: 31.11
+	Hs
		338001 EGFR_HUMAN (1-1210): 0: 1241: 100.00		S10A7_HUMAN (3-93): 4.96e-18: 74.1: 23.66
+	Hs
		642945 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		S10A4_HUMAN (1-101): 9.21e-39: 126: 100.00
+	Hs
		685170 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		S10AB_HUMAN (2-97): 2.99e-36: 120: 27.84
+	Hs
		893799 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		S10AA_HUMAN (1-100): 4.52e-32: 109: 34.00
+	Hs
		383643 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		S10AB_HUMAN (2-97): 2.99e-36: 120: 27.84
+	Hs
		601812 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		S10A4_HUMAN (1-101): 9.21e-39: 126: 100.00
+	Hs
		383930 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		S10AG_HUMAN (3-83): 1.43e-23: 87.9: 37.81
+	Hs
		383989 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		S10AE_HUMAN (3-84): 7.11e-20: 78.7: 28.05
+	Hs
		601869 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		S10AA_HUMAN (1-100): 4.52e-32: 109: 34.00
+	Hs
		380734 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		S100B_HUMAN (3-91): 3.86e-31: 106: 47.19
+	Hs
		416337 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		S10A9_HUMAN (3-91): 3.65e-28: 99.9: 31.11
+	Hs
		396674 INSRR_HUMAN (352-656): 3.99e-25: 115: 20.90		S10A8_HUMAN (1-88): 8.31e-25: 91: 29.55