HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: CALX (P27824)
Calnexin (IP90) (Major histocompatibility complex class I antigen-binding protein p88) (p90)
Gene: CANX

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	24797263, 24189400, 28065597, 25754235
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005789 - endoplasmic reticulum membrane GO:0016020 - membrane GO:0031965 - nuclear membrane
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 592
+	Hs
		383628 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		CALX_HUMAN (1-592): 0: 786: 100.00
+	Hs
		601814 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		CALX_HUMAN (1-592): 0: 786: 100.00
+	Hs
		160994 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		CLGN_HUMAN (11-546): 0: 652: 59.85
+	Hs
		161016 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		CLGN_HUMAN (11-546): 0: 652: 59.85
+	Hs
		337975 EGFR_HUMAN (1-1210): 0: 1241: 100.00		CALR_HUMAN (67-470): 1.19e-141: 418: 38.33
+	Hs
		434139 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		CALX_HUMAN (1-592): 0: 786: 100.00
+	Hs
		411305 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		CALX_HUMAN (1-592): 0: 786: 100.00
+	Hs
		654090 EPHA3_HUMAN (654-981): 7.78e-111: 372: 34.51		CALX_HUMAN (1-592): 0: 786: 100.00
+	Hs
		161002 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		CLGN_HUMAN (11-546): 0: 652: 59.85
+	Hs
		160999 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		CLGN_HUMAN (11-546): 0: 652: 59.85
+	Hs
		654147 KSYK_HUMAN (716-961): 1.13e-53: 201: 41.70		CALX_HUMAN (1-592): 0: 786: 100.00
+	Hs
		435545 IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47		CALX_HUMAN (1-592): 0: 786: 100.00
+	Rn
		544766 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		CALR_RAT (67-470): 7.8e-147: 431: 37.35
+	Hs
		161003 IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47		CLGN_HUMAN (11-546): 0: 652: 59.85