HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: S10AB (P31949)
Protein S100-A11 (Calgizzarin) (Metastatic lymph node gene 70 protein) (MLN 70) (Protein S100-C) (S100 calcium-binding protein A11) [Cleaved into: Protein S100-A11, N-terminally processed]
Gene: S100A11

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	15657067
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005615 - extracellular space GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0007165 - signal transduction
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 105
+	Hs
		338660 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HORN_HUMAN (9-104): 4.97e-34: 125: 27.00
+	Hs
		338220 EGFR_HUMAN (1-1210): 0: 1241: 100.00		S10AA_HUMAN (7-104): 1.06e-37: 123: 36.74
+	Hs
		337962 EGFR_HUMAN (1-1210): 0: 1241: 100.00		S10A4_HUMAN (9-103): 6.62e-35: 116: 28.42
+	Hs
		337773 EGFR_HUMAN (1-1210): 0: 1241: 100.00		S10A9_HUMAN (8-98): 4.61e-33: 112: 35.87
+	Hs
		338001 EGFR_HUMAN (1-1210): 0: 1241: 100.00		S10A7_HUMAN (6-100): 2.65e-24: 90: 32.99
+	Hs
		685170 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		S10AB_HUMAN (1-105): 1.4e-46: 146: 100.00
+	Hs
		893799 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		S10AA_HUMAN (7-104): 1.06e-37: 123: 36.74
+	Hs
		383643 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		S10AB_HUMAN (1-105): 1.4e-46: 146: 100.00
+	Hs
		642945 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		S10A4_HUMAN (9-103): 6.62e-35: 116: 28.42
+	Hs
		383930 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		S10AG_HUMAN (8-101): 4.75e-27: 97.3: 25.26
+	Hs
		601869 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		S10AA_HUMAN (7-104): 1.06e-37: 123: 36.74
+	Hs
		383989 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		S10AE_HUMAN (8-89): 2.78e-22: 85: 28.05
+	Hs
		601812 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		S10A4_HUMAN (9-103): 6.62e-35: 116: 28.42
+	Hs
		380734 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		S100B_HUMAN (8-95): 7.04e-33: 111: 36.36
+	Hs
		416337 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		S10A9_HUMAN (8-98): 4.61e-33: 112: 35.87
+	Hs
		396674 INSRR_HUMAN (352-656): 3.99e-25: 115: 20.90		S10A8_HUMAN (8-102): 9.02e-30: 103: 26.32