HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: K22E (P35908)
Keratin, type II cytoskeletal 2 epidermal (Cytokeratin-2e) (CK-2e) (Epithelial keratin-2e) (Keratin-2 epidermis) (Keratin-2e) (K2e) (Type-II keratin Kb2)
Gene: KRT2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	28065597
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005615 - extracellular space GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0016020 - membrane
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 639
+	Hs
		337744 EGFR_HUMAN (1-1210): 0: 1241: 100.00		K2C1_HUMAN (143-509): 1.63e-112: 353: 71.94
+	Hs
		213922 EGFR_HUMAN (1-1210): 0: 1241: 100.00		KRT86_HUMAN (72-557): 8.74e-87: 281: 44.35
+	Hs
		337855 EGFR_HUMAN (1-1210): 0: 1241: 100.00		K2C5_HUMAN (1-494): 7.49e-82: 271: 61.48
+	Hs
		337731 EGFR_HUMAN (1-1210): 0: 1241: 100.00		K2C6A_HUMAN (5-510): 8.33e-78: 259: 61.22
+	Hs
		337847 EGFR_HUMAN (1-1210): 0: 1241: 100.00		K2C3_HUMAN (27-494): 2.18e-66: 230: 64.32
+	Hs
		537730 INSRR_HUMAN (352-656): 3.99e-25: 115: 20.90		KRT83_HUMAN (83-491): 2.11e-86: 280: 49.02
+	Hs
		380436 IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47		K2C6B_HUMAN (5-510): 8.35e-82: 270: 61.22