Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR
Interactor 2: STAT3 (P40763)
Signal transducer and activator of transcription 3 (Acute-phase response factor)
Gene: STAT3
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
Method score | Annotation score | Interaction score |
---|---|---|
0.97 | 1.00 | 0.989 |
The method score is based on:
Property | Details |
---|---|
Experiments | 24135280, 12873986, 20067773, 21573184, 15284024, 25402006, 24658140, 24189400, 18258752, 15485908, 24240702, 25754235, 10358079, 15950906, 9756944, 23956138, 14963038, unassigned2173, 15657067, 14966128 |
Identification Methods | affinity chromatography technology, pull down, two hybrid, protein complementation assay, enzymatic study, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, ubiquitin reconstruction, tandem affinity purification |
Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
Property | Details |
---|---|
Interacting Pfam domains | PK_Tyr_Ser-Thr~SH2 |
Common GO terms | GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0019901 - protein kinase binding and 5 others more... |
Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores
Service provided by Combinatics, Japan
Last updated: 15 Jul 2024