Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR
Interactor 2: STAT1 (P42224)
Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84)
Gene: STAT1
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.94 | 1.00 | 0.972 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 15284024, 25402006, 24658140, 10358079, 12070153, 23956138, 24797263, unassigned2173 |
| Identification Methods | affinity chromatography technology, two hybrid, protein complementation assay, anti tag coimmunoprecipitation, competition binding, luminescence based mammalian interactome mapping, ubiquitin reconstruction, electrophoretic mobility shift assay |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | PK_Tyr_Ser-Thr~SH2 |
| Common GO terms | GO:0003690 - double-stranded DNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0019899 - enzyme binding GO:0032991 - protein-containing complex and 5 others more... |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
