HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: MATK (P42679)
Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (CSK homologous kinase) (CHK) (Hematopoietic consensus tyrosine-lacking kinase) (Protein kinase HYL) (Tyrosine-protein kinase CTK)
Gene: MATK

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	9461599
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0004713 - protein tyrosine kinase activity GO:0005524 - ATP binding GO:0008284 - positive regulation of cell population proliferation GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 507
+	Mm
		403432 EGFR_MOUSE (1-1210): 0: 1258: 90.35		SRC_MOUSE (14-493): 0: 523: 34.07
+	Hs
		337789 EGFR_HUMAN (1-1210): 0: 1241: 100.00		YES_HUMAN (4-493): 0: 523: 31.94
+	Hs
		337850 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SRC_HUMAN (30-493): 0: 523: 34.52
+	Rn
		1351588 Q9QX70_RAT (1-1210): 0: 1241: 90.34		SRC_RAT (30-493): 0: 519: 34.52
+	Hs
		337821 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FGR_HUMAN (4-494): 0: 519: 32.03
+	Hs
		337769 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LCK_HUMAN (39-492): 1.32e-180: 518: 34.62
+	Hs
		337804 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HCK_HUMAN (26-490): 3.62e-178: 512: 33.47
+	Hs
		338084 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FRK_HUMAN (22-494): 1.41e-173: 500: 30.91
+	Hs
		337294 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ABL1_HUMAN (26-486): 1.44e-165: 499: 32.70
+	Hs
		338069 EGFR_HUMAN (1-1210): 0: 1241: 100.00		CSK_HUMAN (45-485): 8.23e-174: 498: 53.05
+	Hs
		338083 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ABL2_HUMAN (13-503): 2.01e-164: 498: 31.37
+	Hs
		337790 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LYN_HUMAN (14-490): 4.73e-171: 493: 31.73
+	Hs
		338331 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ITK_HUMAN (33-484): 4.01e-169: 493: 33.12
+	Hs
		338144 EGFR_HUMAN (1-1210): 0: 1241: 100.00		BLK_HUMAN (10-492): 2.69e-169: 489: 32.66
+	Hs
		338082 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TXK_HUMAN (1-484): 1.5e-154: 452: 29.47
+	Hs
		338081 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TEC_HUMAN (16-490): 3.23e-152: 450: 29.41
+	Hs
		411729 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		LCK_HUMAN (39-492): 1.32e-180: 518: 34.62
+	Hs
		337480 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		ABL1_HUMAN (26-486): 1.44e-165: 499: 32.70
+	Hs
		337884 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FER_HUMAN (75-478): 2.04e-80: 268: 38.86
+	Hs
		338406 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTK6_HUMAN (66-479): 8.11e-80: 258: 38.73