HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: FRK (P42685)
Tyrosine-protein kinase FRK (EC 2.7.10.2) (FYN-related kinase) (Nuclear tyrosine protein kinase RAK) (Protein-tyrosine kinase 5)
Gene: FRK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.858

Property	Details
Experiments	25402006, 24658140, unassigned2173
Identification Methods	two hybrid, protein complementation assay, affinity chromatography technology, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0004713 - protein tyrosine kinase activity GO:0005524 - ATP binding GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 505
+	Mm
		403432 EGFR_MOUSE (1-1210): 0: 1258: 90.35		SRC_MOUSE (10-503): 1.14e-177: 511: 47.40
+	Hs
		337850 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SRC_HUMAN (13-503): 1.23e-178: 513: 47.89
+	Rn
		1351588 Q9QX70_RAT (1-1210): 0: 1241: 90.34		SRC_RAT (13-503): 3.55e-177: 510: 47.69
+	Hs
		337804 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HCK_HUMAN (3-496): 2.62e-175: 505: 48.61
+	Hs
		337789 EGFR_HUMAN (1-1210): 0: 1241: 100.00		YES_HUMAN (43-503): 6.27e-174: 502: 49.25
+	Hs
		337769 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LCK_HUMAN (33-495): 2.21e-173: 499: 48.50
+	Hs
		338331 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ITK_HUMAN (5-493): 3.16e-171: 498: 33.47
+	Hs
		338081 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TEC_HUMAN (5-497): 6.24e-170: 495: 33.72
+	Hs
		337821 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FGR_HUMAN (33-502): 1.94e-169: 490: 50.00
+	Hs
		338082 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TXK_HUMAN (7-493): 5.29e-169: 489: 34.14
+	Hs
		337294 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ABL1_HUMAN (33-495): 1.24e-159: 484: 42.03
+	Hs
		337790 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LYN_HUMAN (21-495): 3.53e-166: 481: 49.27
+	Hs
		338069 EGFR_HUMAN (1-1210): 0: 1241: 100.00		CSK_HUMAN (48-494): 6.43e-167: 480: 36.78
+	Hs
		338083 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ABL2_HUMAN (29-502): 4.71e-157: 478: 41.05
+	Hs
		338406 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTK6_HUMAN (44-490): 1.08e-165: 478: 43.53
+	Hs
		338144 EGFR_HUMAN (1-1210): 0: 1241: 100.00		BLK_HUMAN (10-496): 1.72e-162: 471: 46.34
+	Hs
		412202 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		FYN_HUMAN (30-503): 1.55e-177: 511: 50.63
+	Hs
		433359 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		YES_HUMAN (43-503): 6.27e-174: 502: 49.25
+	Hs
		411729 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		LCK_HUMAN (33-495): 2.21e-173: 499: 48.50
+	Hs
		337480 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		ABL1_HUMAN (33-495): 1.24e-159: 484: 42.03