HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: LIFR (P42702)
Leukemia inhibitory factor receptor (LIF receptor) (LIF-R) (CD antigen CD118)
Gene: LIFR

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Furin-like~fn3, PK_Tyr_Ser-Thr~fn3, Recep_L_domain~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0007166 - cell surface receptor signaling pathway GO:0008284 - positive regulation of cell population proliferation GO:0043235 - receptor complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 1097
+	Mm
		250890 EGFR_MOUSE (1-1210): 0: 1258: 90.35		OSMR_MOUSE (133-941): 9.9e-117: 386: 28.64
+	Hs
		337831 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRF_HUMAN (3-1045): 1.71e-100: 352: 13.12
+	Hs
		337941 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRD_HUMAN (3-1091): 2.08e-98: 345: 13.27
+	Rn
		984693 Q8K3F9_RAT (5-1200): 0: 1129: 48.85		L1CAM_RAT (27-1008): 1.03e-81: 293: 10.06
+	Hs
		338300 EGFR_HUMAN (1-1210): 0: 1241: 100.00		CNTN2_HUMAN (147-1042): 1.92e-39: 161: 11.02
+	Hs
		338012 EGFR_HUMAN (1-1210): 0: 1241: 100.00		L1CAM_HUMAN (318-1059): 1.18e-27: 123: 10.45
+	Rn
		984692 ERBB3_RAT (1-1180): 0: 1070: 41.32		L1CAM_RAT (27-1008): 1.03e-81: 293: 10.06
+	Hs
		338057 EGFR_HUMAN (1-1210): 0: 1241: 100.00		IL6RB_HUMAN (42-531): 3.09e-13: 76.6: 15.58
+	Hs
		338888 EGFR_HUMAN (1-1210): 0: 1241: 100.00		OSMR_HUMAN (50-542): 4.28e-12: 72.8: 11.87
+	Hs
		383644 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		L1CAM_HUMAN (318-1059): 1.18e-27: 123: 10.45
+	Hs
		601825 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		L1CAM_HUMAN (318-1059): 1.18e-27: 123: 10.45
+	Hs
		383660 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		IL6RB_HUMAN (42-531): 3.09e-13: 76.6: 15.58
+	Hs
		383948 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		OSMR_HUMAN (50-542): 4.28e-12: 72.8: 11.87
+	Hs
		601828 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		IL6RB_HUMAN (42-531): 3.09e-13: 76.6: 15.58
+	Hs
		434120 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		PTPRF_HUMAN (3-1045): 1.71e-100: 352: 13.12
+	Rn
		544873 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		CNTN1_RAT (144-1093): 9.36e-70: 255: 9.63
+	Hs
		796636 KSYK_HUMAN (716-961): 1.13e-53: 201: 41.70		CSF3R_HUMAN (259-1025): 8.51e-107: 355: 18.67
+	Mm
		514127 FAK1_MOUSE (716-991): 5.99e-54: 207: 37.68		L1CAM_MOUSE (1-1090): 9.99e-84: 299: 10.20
+	Hs
		983646 FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68		NEO1_HUMAN (3-637): 1.82e-43: 174: 13.83
+	Hs
		793638 FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68		DCC_HUMAN (3-681): 1.05e-36: 153: 13.62