HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: AL3A2 (P51648)
Aldehyde dehydrogenase family 3 member A2 (EC 1.2.1.3) (EC 1.2.1.94) (Aldehyde dehydrogenase 10) (Fatty aldehyde dehydrogenase) (Microsomal aldehyde dehydrogenase)
Gene: ALDH3A2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35384245, 23956138
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005789 - endoplasmic reticulum membrane
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 485
+	Hs
		338091 EGFR_HUMAN (1-1210): 0: 1241: 100.00		AL3B1_HUMAN (3-458): 1.23e-167: 482: 53.73
+	Hs
		383700 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		AL3A2_HUMAN (1-485): 0: 524: 100.00
+	Hs
		601857 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		AL3A2_HUMAN (1-485): 0: 524: 100.00
+	Hs
		434162 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		AL3A2_HUMAN (1-485): 0: 524: 100.00
+	Hs
		411340 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		AL3A2_HUMAN (1-485): 0: 524: 100.00
+	Rn
		102594 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		G3V9W6_RAT (1-464): 1.97e-170: 493: 85.99
+	Hs
		537728 INSRR_HUMAN (352-656): 3.99e-25: 115: 20.90		AL3A2_HUMAN (1-485): 0: 524: 100.00
+	Hs
		435589 IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47		AL3A2_HUMAN (1-485): 0: 524: 100.00