HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: STAT2 (P52630)
Signal transducer and activator of transcription 2 (p113)
Gene: STAT2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.843

Property	Details
Experiments	25402006, 24658140, unassigned2173
Identification Methods	two hybrid, protein complementation assay, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005634 - nucleus GO:0005886 - plasma membrane GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 851
+	Hs
		338072 EGFR_HUMAN (1-1210): 0: 1241: 100.00		STAT1_HUMAN (1-728): 0: 879: 42.36
+	Hs
		338060 EGFR_HUMAN (1-1210): 0: 1241: 100.00		STAT3_HUMAN (1-747): 0: 846: 37.47
+	Hs
		338073 EGFR_HUMAN (1-1210): 0: 1241: 100.00		STA5A_HUMAN (1-769): 0: 789: 24.67
+	Hs
		338153 EGFR_HUMAN (1-1210): 0: 1241: 100.00		STA5B_HUMAN (1-768): 0: 774: 24.67
+	Hs
		383667 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		STAT1_HUMAN (1-728): 0: 879: 42.36
+	Mm
		786519 ERBB2_MOUSE (5-1200): 0: 1116: 48.46		STAT3_MOUSE (1-747): 0: 846: 37.47
+	Hs
		383662 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		STAT3_HUMAN (1-747): 0: 846: 37.47
+	Hs
		786612 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		STA5A_HUMAN (1-769): 0: 789: 24.67
+	Hs
		849893 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		STA5B_HUMAN (1-768): 0: 774: 24.67
+	Hs
		434150 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		STAT3_HUMAN (1-747): 0: 846: 37.47
+	Rn
		94369 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		F1M9D6_RAT (1-730): 0: 882: 42.71
+	Hs
		411328 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		STAT3_HUMAN (1-747): 0: 846: 37.47
+	Hs
		849879 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		STA5B_HUMAN (1-768): 0: 774: 24.67
+	Hs
		411330 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		STA5A_HUMAN (1-769): 0: 789: 24.67
+	Hs
		411341 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		STA5B_HUMAN (1-768): 0: 774: 24.67
+	Hs
		786328 ACK1_HUMAN (691-967): 4.54e-56: 214: 39.58		STAT1_HUMAN (1-728): 0: 879: 42.36
+	Hs
		786322 FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68		STAT1_HUMAN (1-728): 0: 879: 42.36
+	Hs
		776657 FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68		STAT3_HUMAN (1-747): 0: 846: 37.47
+	Hs
		776597 ABL2_HUMAN (707-974): 5.53e-52: 202: 40.37		STAT3_HUMAN (1-747): 0: 846: 37.47
+	Hs
		776598 KSYK_HUMAN (716-961): 1.13e-53: 201: 41.70		STAT3_HUMAN (1-747): 0: 846: 37.47