HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: VAV2 (P52735)
Guanine nucleotide exchange factor VAV2 (VAV-2)
Gene: VAV2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.951

Property	Details
Experiments	10938113, 20940296, 22973453, 19531499, 18271526, 24797263, 12454019
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	C1_1~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0071466 - cellular response to xenobiotic stimulus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 878
+	Hs
		855797 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		VAV2_HUMAN (1-878): 0: 658: 100.00
+	Mm
		654977 EGFR_MOUSE (1-1210): 0: 1258: 90.35		VAV_MOUSE (1-875): 8.6e-174: 526: 47.76
+	Hs
		339121 EGFR_HUMAN (1-1210): 0: 1241: 100.00		VAV3_HUMAN (1-875): 1.54e-178: 538: 49.61
+	Hs
		337872 EGFR_HUMAN (1-1210): 0: 1241: 100.00		VAV_HUMAN (1-875): 8.4e-175: 529: 47.20
+	Hs
		383705 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		VAV2_HUMAN (1-878): 0: 658: 100.00
+	Hs
		338823 EGFR_HUMAN (1-1210): 0: 1241: 100.00		Q96D37_HUMAN (66-875): 3.75e-154: 473: 45.24
+	Hs
		1071026 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		VAV3_HUMAN (1-875): 1.54e-178: 538: 49.61
+	Hs
		548711 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		VAV_HUMAN (1-875): 8.4e-175: 529: 47.20
+	Hs
		384022 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		VAV3_HUMAN (1-875): 1.54e-178: 538: 49.61
+	Hs
		383580 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		VAV_HUMAN (1-875): 8.4e-175: 529: 47.20
+	Hs
		383927 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		Q96D37_HUMAN (66-875): 3.75e-154: 473: 45.24
+	Hs
		224717 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		KALRN_HUMAN (164-650): 4.79e-62: 231: 15.81
+	Mm
		964571 EGFR_MOUSE (1-1210): 0: 1258: 90.35		ARHG7_MOUSE (743-874): 2.46e-13: 76: 24.24
+	Mm
		964559 EGFR_MOUSE (1-1210): 0: 1258: 90.35		GRB2_MOUSE (821-873): 5.79e-11: 65.2: 39.62
+	Hs
		338419 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ARHG7_HUMAN (684-877): 7.11e-14: 78: 18.00
+	Hs
		338478 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ITSN1_HUMAN (343-873): 2.52e-12: 73.2: 12.61
+	Hs
		338251 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GRB2_HUMAN (821-873): 5.47e-11: 65.2: 39.62
+	Rn
		924998 Q9QX70_RAT (1-1210): 0: 1241: 90.34		GRB2_RAT (821-873): 5.47e-11: 65.2: 39.62
+	Hs
		924589 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		GRB2_HUMAN (821-873): 5.47e-11: 65.2: 39.62
+	Hs
		383730 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		GRB2_HUMAN (821-873): 5.47e-11: 65.2: 39.62