HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: AP2S1 (P53680)
AP-2 complex subunit sigma (Adaptor protein complex AP-2 subunit sigma) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (HA2 17 kDa subunit) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma2-adaptin)
Gene: AP2S1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	24189400, 25754235, 35384245, 24797263
Identification Methods	affinity chromatography technology, proximity labelling technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0030669 - clathrin-coated endocytic vesicle membrane
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 142
+	Hs
		338777 EGFR_HUMAN (1-1210): 0: 1241: 100.00		AP3S1_HUMAN (1-142): 5.3e-51: 162: 40.54
+	Hs
		338197 EGFR_HUMAN (1-1210): 0: 1241: 100.00		AP1S2_HUMAN (2-142): 5.11e-51: 161: 46.10
+	Hs
		338229 EGFR_HUMAN (1-1210): 0: 1241: 100.00		AP1S1_HUMAN (1-142): 2.51e-51: 161: 44.37
+	Hs
		339212 EGFR_HUMAN (1-1210): 0: 1241: 100.00		AP1M2_HUMAN (2-142): 3.16e-44: 151: 19.44
+	Hs
		338940 EGFR_HUMAN (1-1210): 0: 1241: 100.00		AP1M1_HUMAN (2-137): 4.68e-44: 150: 14.71
+	Hs
		338822 EGFR_HUMAN (1-1210): 0: 1241: 100.00		AP2M1_HUMAN (1-138): 1.82e-41: 144: 15.22
+	Hs
		384056 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		AP1M2_HUMAN (2-142): 3.16e-44: 151: 19.44
+	Hs
		602043 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		AP1M2_HUMAN (2-142): 3.16e-44: 151: 19.44
+	Zm
		16000 A0A1D6GJ33_MAIZE (342-1030): 8.56e-139: 447: 14.94		A0A1D6L6Q4_MAIZE (1-141): 1.96e-59: 187: 48.94
+	Hs
		872628 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		COPZ1_HUMAN (2-138): 3.65e-44: 144: 22.30
+	Hs
		665183 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		AP2S1_HUMAN (1-142): 6.18e-46: 147: 100.00
+	Hs
		665310 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		AP2M1_HUMAN (1-138): 1.82e-41: 144: 15.22
+	Rn
		78210 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		B5DFI3_RAT (1-142): 2.51e-51: 161: 44.37
+	Rn
		544829 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		AP1M1_RAT (2-137): 3.99e-44: 151: 14.71
+	Rn
		544815 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		AP2M1_RAT (1-138): 1.82e-41: 144: 15.22