HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: XPO2 (P55060)
Exportin-2 (Exp2) (Cellular apoptosis susceptibility protein) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)
Gene: CSE1L

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.676

Property	Details
Experiments	28065597, 35384245, 23956138, 15657067
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0016020 - membrane
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 971
+	Hs
		178088 EGFR_HUMAN (1-1210): 0: 1241: 100.00		IPO8_HUMAN (7-962): 1.26e-161: 503: 18.13
+	Hs
		312152 EGFR_HUMAN (1-1210): 0: 1241: 100.00		IPO7_HUMAN (7-880): 9.51e-158: 493: 19.02
+	Hs
		155507 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TNPO2_HUMAN (1-861): 4.17e-128: 411: 12.97
+	Hs
		338800 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TNPO1_HUMAN (2-861): 1.05e-127: 410: 13.35
+	Hs
		339100 EGFR_HUMAN (1-1210): 0: 1241: 100.00		IPO11_HUMAN (1-966): 7.87e-116: 380: 15.29
+	Hs
		338858 EGFR_HUMAN (1-1210): 0: 1241: 100.00		IPO9_HUMAN (8-923): 1.04e-112: 373: 14.79
+	Hs
		383912 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		TNPO1_HUMAN (2-861): 1.05e-127: 410: 13.35
+	Hs
		127154 EGFR_HUMAN (1-1210): 0: 1241: 100.00		IPO5_HUMAN (90-886): 1.85e-18: 93.4: 11.41
+	Mm
		796521 ZAP70_MOUSE (718-961): 2.03e-52: 197: 40.00		XPO2_MOUSE (1-971): 0: 781: 99.07
+	Hs
		435716 IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47		TNPO1_HUMAN (2-861): 1.05e-127: 410: 13.35