HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: RND3 (P61587)
Rho-related GTP-binding protein RhoE (Protein MemB) (Rho family GTPase 3) (Rho-related GTP-binding protein Rho8) (Rnd3)
Gene: RND3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000139 - Golgi membrane GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0007165 - signal transduction GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 244
+	Hs
		338161 EGFR_HUMAN (1-1210): 0: 1241: 100.00		RND2_HUMAN (20-244): 3.9e-103: 300: 64.00
+	Hs
		337796 EGFR_HUMAN (1-1210): 0: 1241: 100.00		RHOC_HUMAN (22-213): 2.02e-92: 271: 49.48
+	Hs
		338788 EGFR_HUMAN (1-1210): 0: 1241: 100.00		RND1_HUMAN (1-244): 1.22e-90: 268: 58.20
+	Hs
		338244 EGFR_HUMAN (1-1210): 0: 1241: 100.00		RHOB_HUMAN (22-200): 2.38e-90: 266: 50.84
+	Hs
		338221 EGFR_HUMAN (1-1210): 0: 1241: 100.00		CDC42_HUMAN (24-208): 1.29e-82: 246: 40.00
+	Hs
		338247 EGFR_HUMAN (1-1210): 0: 1241: 100.00		RAB1A_HUMAN (13-242): 7.48e-80: 240: 22.08
+	Hs
		338253 EGFR_HUMAN (1-1210): 0: 1241: 100.00		RAC1_HUMAN (24-210): 3.03e-80: 240: 43.32
+	Hs
		337868 EGFR_HUMAN (1-1210): 0: 1241: 100.00		RAC2_HUMAN (24-211): 1.42e-76: 231: 39.89
+	Hs
		338226 EGFR_HUMAN (1-1210): 0: 1241: 100.00		RHOA_HUMAN (25-207): 1.21e-76: 231: 50.27
+	Hs
		338217 EGFR_HUMAN (1-1210): 0: 1241: 100.00		RAC3_HUMAN (24-199): 1.42e-75: 229: 43.75
+	Hs
		338277 EGFR_HUMAN (1-1210): 0: 1241: 100.00		RHOG_HUMAN (23-208): 1.85e-74: 226: 42.47
+	Hs
		120267 EGFR_HUMAN (1-1210): 0: 1241: 100.00		RHOD_HUMAN (25-211): 1.61e-54: 176: 41.18
+	Hs
		339002 EGFR_HUMAN (1-1210): 0: 1241: 100.00		RHOF_HUMAN (25-212): 1.18e-52: 171: 45.21
+	Hs
		337888 EGFR_HUMAN (1-1210): 0: 1241: 100.00		RHOQ_HUMAN (25-212): 8.64e-51: 166: 42.02
+	Hs
		383726 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		RHOB_HUMAN (22-200): 2.38e-90: 266: 50.84
+	Hs
		383721 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		CDC42_HUMAN (24-208): 1.29e-82: 246: 40.00
+	Hs
		383971 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		RAB1B_HUMAN (16-242): 1.54e-76: 231: 21.49
+	Hs
		383720 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		RAC3_HUMAN (24-199): 1.42e-75: 229: 43.75
+	Hs
		120273 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		RHOD_HUMAN (25-211): 1.61e-54: 176: 41.18
+	Hs
		665573 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		RHOB_HUMAN (22-200): 2.38e-90: 266: 50.84