HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: AP1S1 (P61966)
AP-1 complex subunit sigma-1A (Adaptor protein complex AP-1 subunit sigma-1A) (Adaptor-related protein complex 1 subunit sigma-1A) (Clathrin assembly protein complex 1 sigma-1A small chain) (Clathrin coat assembly protein AP19) (Golgi adaptor HA1/AP1 adaptin sigma-1A subunit) (HA1 19 kDa subunit) (Sigma 1a subunit of AP-1 clathrin) (Sigma-adaptin 1A) (Sigma1A-adaptin)
Gene: AP1S1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	23956138, 24797263
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000139 - Golgi membrane GO:0016020 - membrane
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 158
+	Hs
		338197 EGFR_HUMAN (1-1210): 0: 1241: 100.00		AP1S2_HUMAN (2-157): 6.27e-54: 169: 87.82
+	Hs
		338777 EGFR_HUMAN (1-1210): 0: 1241: 100.00		AP3S1_HUMAN (1-146): 3.41e-50: 160: 36.18
+	Hs
		338822 EGFR_HUMAN (1-1210): 0: 1241: 100.00		AP2M1_HUMAN (1-158): 6.58e-47: 159: 16.98
+	Hs
		338940 EGFR_HUMAN (1-1210): 0: 1241: 100.00		AP1M1_HUMAN (3-154): 3.03e-45: 154: 18.07
+	Hs
		339212 EGFR_HUMAN (1-1210): 0: 1241: 100.00		AP1M2_HUMAN (3-155): 1.92e-43: 150: 19.11
+	Hs
		338175 EGFR_HUMAN (1-1210): 0: 1241: 100.00		AP2S1_HUMAN (1-142): 3.82e-44: 143: 44.37
+	Hs
		384056 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		AP1M2_HUMAN (3-155): 1.92e-43: 150: 19.11
+	Hs
		602043 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		AP1M2_HUMAN (3-155): 1.92e-43: 150: 19.11
+	Zm
		16000 A0A1D6GJ33_MAIZE (342-1030): 8.56e-139: 447: 14.94		A0A1D6L6Q4_MAIZE (1-155): 1.7e-61: 193: 56.13
+	Hs
		665310 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		AP2M1_HUMAN (1-158): 6.58e-47: 159: 16.98
+	Hs
		872628 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		COPZ1_HUMAN (2-152): 1.21e-43: 143: 19.61
+	Rn
		78210 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		B5DFI3_RAT (1-158): 1.33e-54: 170: 100.00
+	Hs
		665183 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		AP2S1_HUMAN (1-142): 3.82e-44: 143: 44.37
+	Rn
		544815 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		AP2M1_RAT (1-158): 6.58e-47: 159: 16.98
+	Rn
		544829 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		AP1M1_RAT (3-154): 2.61e-45: 154: 18.07