HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	34079125, 31871319
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0007165 - signal transduction GO:0010008 - endosome membrane and 1 others more... GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 196
+	Hs
		338253 EGFR_HUMAN (1-1210): 0: 1241: 100.00		RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10
+	Hs
		338226 EGFR_HUMAN (1-1210): 0: 1241: 100.00		RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67
+	Hs
		337868 EGFR_HUMAN (1-1210): 0: 1241: 100.00		RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57
+	Hs
		337796 EGFR_HUMAN (1-1210): 0: 1241: 100.00		RHOC_HUMAN (1-196): 8.84e-76: 227: 83.16
+	Hs
		338277 EGFR_HUMAN (1-1210): 0: 1241: 100.00		RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53
+	Hs
		338217 EGFR_HUMAN (1-1210): 0: 1241: 100.00		RAC3_HUMAN (1-179): 1.15e-74: 224: 57.54
+	Hs
		338221 EGFR_HUMAN (1-1210): 0: 1241: 100.00		CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49
+	Hs
		337888 EGFR_HUMAN (1-1210): 0: 1241: 100.00		RHOQ_HUMAN (2-195): 6.71e-68: 207: 51.74
+	Hs
		120267 EGFR_HUMAN (1-1210): 0: 1241: 100.00		RHOD_HUMAN (7-182): 3.37e-66: 203: 53.98
+	Hs
		383726 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00
+	Hs
		383720 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		RAC3_HUMAN (1-179): 1.15e-74: 224: 57.54
+	Hs
		383721 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49
+	Hs
		120273 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		RHOD_HUMAN (7-182): 3.37e-66: 203: 53.98
+	Hs
		665573 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00
+	Hs
		900497 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67
+	Hs
		545394 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57
+	Hs
		436317 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		RHOC_HUMAN (1-196): 8.84e-76: 227: 83.16
+	Hs
		892660 EPHA6_HUMAN (629-1016): 8.37e-118: 393: 27.80		RAC3_HUMAN (1-179): 1.15e-74: 224: 57.54
+	Hs
		892388 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		RAC3_HUMAN (1-179): 1.15e-74: 224: 57.54
+	Hs
		564541 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		RHOQ_HUMAN (2-195): 6.71e-68: 207: 51.74