Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR
Interactor 2: SOS1 (Q07889)
Son of sevenless homolog 1 (SOS-1)
Gene: SOS1
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.95 | 1.00 | 0.980 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 10675333, 9447973, 20473329, 8621459, 25754235, 31959764, 7510700, 36736316, 19531499, 19289468, 18271526, 23956138, 24797263, 26005835, 34591642 |
| Identification Methods | affinity chromatography technology, pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | PH~PK_Tyr_Ser-Thr |
| Common GO terms | GO:0001942 - hair follicle development GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0007173 - epidermal growth factor receptor signaling pathway and 1 others more... |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
