HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: ARHG5 (Q12774)
Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM)
Gene: ARHGEF5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	25754235, 35384245, 23956138
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 1597
+	Hs
		383768 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		ARHG5_HUMAN (1-1597): 7.13e-161: 532: 100.00
+	Mm
		654977 EGFR_MOUSE (1-1210): 0: 1258: 90.35		VAV_MOUSE (1094-1525): 1.95e-84: 298: 14.48
+	Hs
		338478 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ITSN1_HUMAN (56-1523): 8.75e-83: 303: 12.75
+	Hs
		337872 EGFR_HUMAN (1-1210): 0: 1241: 100.00		VAV_HUMAN (1127-1525): 1.6e-84: 298: 15.92
+	Hs
		338823 EGFR_HUMAN (1-1210): 0: 1241: 100.00		Q96D37_HUMAN (1127-1525): 5.42e-85: 298: 15.92
+	Hs
		339058 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ITSN2_HUMAN (767-1521): 1.68e-79: 293: 14.54
+	Hs
		339121 EGFR_HUMAN (1-1210): 0: 1241: 100.00		VAV3_HUMAN (1127-1523): 5.41e-80: 285: 14.36
+	Hs
		338167 EGFR_HUMAN (1-1210): 0: 1241: 100.00		VAV2_HUMAN (1094-1525): 8.15e-78: 279: 14.58
+	Hs
		548711 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		VAV_HUMAN (1127-1525): 1.6e-84: 298: 15.92
+	Hs
		1071026 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		VAV3_HUMAN (1127-1523): 5.41e-80: 285: 14.36
+	Hs
		855797 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		VAV2_HUMAN (1094-1525): 8.15e-78: 279: 14.58
+	Hs
		383580 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		VAV_HUMAN (1127-1525): 1.6e-84: 298: 15.92
+	Hs
		383927 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		Q96D37_HUMAN (1127-1525): 5.42e-85: 298: 15.92
+	Hs
		384022 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		VAV3_HUMAN (1127-1523): 5.41e-80: 285: 14.36
+	Hs
		383705 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		VAV2_HUMAN (1094-1525): 8.15e-78: 279: 14.58
+	Hs
		548637 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		VAV_HUMAN (1127-1525): 1.6e-84: 298: 15.92
+	Hs
		601970 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		Q96D37_HUMAN (1127-1525): 5.42e-85: 298: 15.92
+	Hs
		224717 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		KALRN_HUMAN (1147-1586): 2.29e-59: 229: 16.18
+	Hs
		602023 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		VAV3_HUMAN (1127-1523): 5.41e-80: 285: 14.36
+	Hs
		601860 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		VAV2_HUMAN (1094-1525): 8.15e-78: 279: 14.58