HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: RAB31 (Q13636)
Ras-related protein Rab-31 (Ras-related protein Rab-22B)
Gene: RAB31

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	19725050, 24644286
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0031901 - early endosome membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 195
+	Hs
		337922 EGFR_HUMAN (1-1210): 0: 1241: 100.00		RAB5A_HUMAN (4-195): 4.32e-93: 271: 45.92
+	Hs
		338247 EGFR_HUMAN (1-1210): 0: 1241: 100.00		RAB1A_HUMAN (7-195): 5.95e-87: 256: 38.14
+	Hs
		338238 EGFR_HUMAN (1-1210): 0: 1241: 100.00		RB11A_HUMAN (7-195): 7.42e-82: 243: 35.15
+	Hs
		338205 EGFR_HUMAN (1-1210): 0: 1241: 100.00		RAB25_HUMAN (7-167): 5.51e-46: 152: 41.62
+	Hs
		383698 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		RAB5C_HUMAN (4-195): 2.12e-92: 270: 45.92
+	Hs
		383971 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		RAB1B_HUMAN (7-195): 3.69e-86: 253: 36.79
+	Hs
		592117 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		RAB5A_HUMAN (4-195): 4.32e-93: 271: 45.92
+	Hs
		665173 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		RAB5C_HUMAN (4-195): 2.12e-92: 270: 45.92
+	Rn
		69430 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		B0BN19_RAT (2-195): 8.84e-98: 283: 69.59
+	Hs
		411339 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		RAB5C_HUMAN (4-195): 2.12e-92: 270: 45.92
+	Hs
		665570 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		RAB2A_HUMAN (1-186): 2.7e-82: 244: 36.84
+	Rn
		69451 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		B0BNK1_RAT (4-195): 1.18e-92: 271: 45.92
+	Hs
		895087 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		RAB2A_HUMAN (1-186): 2.7e-82: 244: 36.84
+	Hs
		665193 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		RAB2A_HUMAN (1-186): 2.7e-82: 244: 36.84
+	Hs
		665197 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		RB11A_HUMAN (7-195): 7.42e-82: 243: 35.15
+	Rn
		192819 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		RB11B_RAT (7-195): 1.07e-85: 253: 35.29
+	Rn
		102471 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		G3V6H0_RAT (7-195): 9.99e-86: 252: 37.31
+	Hs
		411350 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		RB11A_HUMAN (7-195): 7.42e-82: 243: 35.15
+	Rn
		544805 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		RB11A_RAT (7-195): 7.42e-82: 243: 35.15
+	Hs
		665189 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		RAB25_HUMAN (7-167): 5.51e-46: 152: 41.62