HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: SHB (Q15464)
SH2 domain-containing adapter protein B
Gene: SHB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	22973453
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 509
+	Rn
		1129188 Q9QX70_RAT (1-1210): 0: 1241: 90.34		SHC1_RAT (98-508): 1.41e-75: 247: 17.98
+	Mm
		957227 EGFR_MOUSE (1-1210): 0: 1258: 90.35		SHC1_MOUSE (105-508): 5.58e-66: 225: 17.12
+	Mm
		403432 EGFR_MOUSE (1-1210): 0: 1258: 90.35		SRC_MOUSE (264-488): 1.12e-63: 218: 18.64
+	Hs
		145963 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SH2B2_HUMAN (56-507): 1.2e-64: 223: 13.94
+	Hs
		337988 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SHC1_HUMAN (105-508): 5.28e-65: 222: 17.27
+	Mm
		222646 EGFR_MOUSE (1-1210): 0: 1258: 90.35		SOCS5_MOUSE (26-489): 7.82e-58: 202: 15.11
+	Rn
		1351588 Q9QX70_RAT (1-1210): 0: 1241: 90.34		SRC_RAT (264-488): 6e-63: 216: 17.30
+	Hs
		208970 EGFR_HUMAN (1-1210): 0: 1241: 100.00		NCK2_HUMAN (157-505): 7.36e-63: 211: 17.45
+	Hs
		337850 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SRC_HUMAN (264-488): 5.65e-61: 211: 18.57
+	Hs
		256842 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SOCS5_HUMAN (26-489): 3.54e-55: 195: 15.21
+	Hs
		337804 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HCK_HUMAN (261-507): 1.14e-54: 193: 15.75
+	Hs
		337821 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FGR_HUMAN (280-509): 1.78e-54: 193: 16.80
+	Hs
		337789 EGFR_HUMAN (1-1210): 0: 1241: 100.00		YES_HUMAN (252-488): 8.79e-54: 191: 17.21
+	Hs
		337883 EGFR_HUMAN (1-1210): 0: 1241: 100.00		NCK1_HUMAN (157-504): 3.1e-55: 191: 14.25
+	Hs
		338251 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GRB2_HUMAN (349-507): 2.61e-46: 162: 15.63
+	Rn
		924998 Q9QX70_RAT (1-1210): 0: 1241: 90.34		GRB2_RAT (349-507): 2.61e-46: 162: 15.63
+	Hs
		338083 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ABL2_HUMAN (354-487): 6.99e-36: 144: 26.12
+	Hs
		337294 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ABL1_HUMAN (354-507): 1.09e-35: 143: 24.03
+	Hs
		338084 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FRK_HUMAN (394-486): 1.26e-17: 87.7: 28.42
+	Hs
		275158 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GRAP2_HUMAN (354-490): 4.56e-18: 87.3: 24.64