Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: LRRK1 (Q38SD2)
Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1)
Gene: LRRK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.861

The method score is based on:

Property Details
Experiments 28065597, 29513927, 24947832
Identification Methods affinity chromatography technology, pull down, anti tag coimmunoprecipitation, protein array
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains COR~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~Pkinase
Common GO terms GO:0005524 - ATP binding
GO:0016020 - membrane
GO:0090263 - positive regulation of canonical Wnt signaling pathway
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1210
Hs

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Last updated: 15 Jul 2024