HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: PTN20 (Q4JDL3)
Tyrosine-protein phosphatase non-receptor type 20 (hPTPN20) (EC 3.1.3.48)
Gene: PTPN20

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.713

Property	Details
Experiments	28065597
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 420
+	Hs
		338350 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTN13_HUMAN (64-416): 4.06e-122: 392: 36.44
+	Hs
		337940 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRB_HUMAN (99-415): 1.61e-121: 390: 32.52
+	Hs
		338349 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRJ_HUMAN (116-416): 2.3e-120: 381: 32.48
+	Hs
		338456 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRR_HUMAN (21-416): 5.94e-125: 377: 25.97
+	Hs
		339009 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRH_HUMAN (128-415): 5.29e-117: 368: 33.45
+	Hs
		337987 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTN6_HUMAN (151-414): 4.03e-119: 360: 35.56
+	Hs
		337903 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTN1_HUMAN (144-417): 8.1e-121: 359: 31.34
+	Hs
		337941 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRD_HUMAN (68-413): 4.26e-106: 346: 31.86
+	Hs
		337831 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRF_HUMAN (68-413): 3.75e-101: 332: 30.19
+	Hs
		337909 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRA_HUMAN (66-413): 8.2e-105: 329: 27.35
+	Hs
		337942 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRE_HUMAN (66-413): 1.19e-92: 295: 26.98
+	Hs
		337802 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRC_HUMAN (122-410): 3.71e-76: 259: 25.85
+	Hs
		146919 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRT_HUMAN (40-415): 1.56e-63: 223: 23.37
+	Hs
		338458 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRK_HUMAN (41-415): 7.63e-63: 221: 21.72
+	Hs
		338787 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRU_HUMAN (138-418): 3.79e-61: 216: 26.25
+	Hs
		337943 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRG_HUMAN (66-418): 6.63e-58: 206: 23.06
+	Hs
		338901 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTN18_HUMAN (177-413): 5.07e-49: 174: 41.13
+	Hs
		337897 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTN2_HUMAN (181-411): 2.23e-45: 163: 36.71
+	Hs
		146927 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		PTPRT_HUMAN (40-415): 1.56e-63: 223: 23.37
+	Rn
		1143998 ERBB4_RAT (7-1199): 0: 1138: 49.38		PTPRZ_RAT (66-413): 6.16e-62: 218: 22.13