HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: SHC4 (Q6S5L8)
SHC-transforming protein 4 (Rai-like protein) (RaLP) (SHC-transforming protein D) (hShcD) (Src homology 2 domain-containing-transforming protein C4) (SH2 domain protein C4)
Gene: SHC4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.952

Property	Details
Experiments	24430869, 25402006, 24658140, 28724758, 22973453, unassigned2173
Identification Methods	affinity chromatography technology, pull down, two hybrid, protein complementation assay, ubiquitin reconstruction, luminescence based mammalian interactome mapping
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0008284 - positive regulation of cell population proliferation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 630
+	Mm
		957227 EGFR_MOUSE (1-1210): 0: 1258: 90.35		SHC1_MOUSE (26-620): 4.38e-150: 447: 46.55
+	Hs
		337988 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SHC1_HUMAN (26-620): 6.45e-150: 447: 45.40
+	Rn
		1129188 Q9QX70_RAT (1-1210): 0: 1241: 90.34		SHC1_RAT (148-620): 1.16e-130: 394: 49.38
+	Rn
		94037 Q9QX70_RAT (1-1210): 0: 1241: 90.34		F1LN91_RAT (26-611): 9.6e-59: 215: 10.79
+	Hs
		331363 EGFR_HUMAN (1-1210): 0: 1241: 100.00		APBA3_HUMAN (20-452): 1.32e-52: 191: 14.41
+	Hs
		337884 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FER_HUMAN (341-629): 8.51e-51: 190: 19.52
+	Mm
		403432 EGFR_MOUSE (1-1210): 0: 1258: 90.35		SRC_MOUSE (385-628): 1.58e-45: 171: 15.59
+	Hs
		145963 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SH2B2_HUMAN (339-622): 5.86e-49: 182: 19.80
+	Hs
		337850 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SRC_HUMAN (385-628): 4.11e-44: 167: 14.77
+	Rn
		1351588 Q9QX70_RAT (1-1210): 0: 1241: 90.34		SRC_RAT (395-628): 7.33e-44: 166: 16.21
+	Hs
		337789 EGFR_HUMAN (1-1210): 0: 1241: 100.00		YES_HUMAN (367-628): 2.22e-43: 165: 16.12
+	Hs
		337779 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FES_HUMAN (384-629): 4.9e-42: 164: 20.16
+	Hs
		275521 EGFR_HUMAN (1-1210): 0: 1241: 100.00		BCAR3_HUMAN (375-619): 1.73e-41: 163: 19.25
+	Hs
		338084 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FRK_HUMAN (423-629): 4.99e-42: 161: 19.73
+	Hs
		337886 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PLCG2_HUMAN (269-630): 5.78e-40: 159: 13.88
+	Hs
		208970 EGFR_HUMAN (1-1210): 0: 1241: 100.00		NCK2_HUMAN (398-618): 7.15e-41: 154: 16.07
+	Hs
		337883 EGFR_HUMAN (1-1210): 0: 1241: 100.00		NCK1_HUMAN (425-615): 6.64e-40: 151: 17.35
+	Hs
		337978 EGFR_HUMAN (1-1210): 0: 1241: 100.00		P85A_HUMAN (506-622): 3.58e-20: 97.1: 24.19
+	Mm
		964559 EGFR_MOUSE (1-1210): 0: 1258: 90.35		GRB2_MOUSE (520-614): 1.23e-13: 72.2: 30.30
+	Rn
		924998 Q9QX70_RAT (1-1210): 0: 1241: 90.34		GRB2_RAT (520-616): 5.11e-14: 73.4: 30.48