HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: MPRIP (Q6WCQ1)
Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip)
Gene: MPRIP

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0005925 - focal adhesion GO:0045296 - cadherin binding GO:0051015 - actin filament binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 1025
+	Hs
		339090 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SWP70_HUMAN (370-824): 7.27e-58: 212: 19.22
+	Hs
		338732 EGFR_HUMAN (1-1210): 0: 1241: 100.00		DLG5_HUMAN (647-1019): 8.88e-54: 207: 21.61
+	Hs
		338965 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TARA_HUMAN (231-985): 1.44e-51: 201: 35.57
+	Hs
		338561 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PKHA7_HUMAN (336-980): 5.04e-41: 166: 13.51
+	Hs
		338998 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PKHA5_HUMAN (318-1019): 7.56e-36: 149: 13.24
+	Hs
		338037 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66
+	Hs
		254427 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ROCK2_HUMAN (446-1018): 6.09e-17: 88.7: 11.81
+	Hs
		601954 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		DLG5_HUMAN (647-1019): 8.88e-54: 207: 21.61
+	Hs
		665271 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		MPRIP_HUMAN (1-1025): 9.29e-127: 412: 100.00
+	Hs
		665293 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		DLG5_HUMAN (647-1019): 8.88e-54: 207: 21.61
+	Mm
		222828 ACK1_MOUSE (691-967): 2.4e-53: 206: 38.87		MPRIP_MOUSE (1-1024): 9.38e-118: 388: 88.01
+	Hs
		665661 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		PKHA5_HUMAN (318-1019): 7.56e-36: 149: 13.24
+	Hs
		1072602 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		PKHA5_HUMAN (318-1019): 7.56e-36: 149: 13.24
+	Hs
		665375 EPHA3_HUMAN (654-981): 7.78e-111: 372: 34.51		MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66
+	Hs
		1189813 EPHA6_HUMAN (629-1016): 8.37e-118: 393: 27.80		MYH14_HUMAN (595-972): 3.69e-09: 63.1: 14.89
+	Hs
		983688 FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68		SWP70_HUMAN (370-824): 7.27e-58: 212: 19.22
+	Mm
		222875 ACK1_MOUSE (691-967): 2.4e-53: 206: 38.87		MYH9_MOUSE (542-1025): 4.68e-18: 92.5: 8.68
+	Mm
		222845 ACK1_MOUSE (691-967): 2.4e-53: 206: 38.87		MYH10_MOUSE (534-1014): 8.31e-16: 85.1: 9.18
+	Hs
		435765 IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47		PKHA5_HUMAN (318-1019): 7.56e-36: 149: 13.24