HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: TENS4 (Q8IZW8)
Tensin-4 (C-terminal tensin-like protein)
Gene: TNS4

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.834

Property	Details
Experiments	22973453, 16273093, 34591642
Identification Methods	pull down, unspecified method, anti tag coimmunoprecipitation, protein array
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 715
+	Rn
		94037 Q9QX70_RAT (1-1210): 0: 1241: 90.34		F1LN91_RAT (6-714): 2.29e-88: 305: 27.08
+	Hs
		338552 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TENS3_HUMAN (1-714): 7.94e-77: 271: 26.80
+	Hs
		338550 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TENS2_HUMAN (129-714): 2.06e-70: 252: 30.86
+	Hs
		339003 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TENS1_HUMAN (9-712): 2.82e-68: 246: 29.79
+	Hs
		1070981 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		TENS4_HUMAN (1-715): 2.96e-94: 309: 100.00
+	Hs
		1070975 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		TENS3_HUMAN (1-714): 7.94e-77: 271: 26.80
+	Hs
		1070974 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		TENS2_HUMAN (129-714): 2.06e-70: 252: 30.86
+	Hs
		1071015 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		TENS1_HUMAN (9-712): 2.82e-68: 246: 29.79
+	Mm
		403432 EGFR_MOUSE (1-1210): 0: 1258: 90.35		SRC_MOUSE (287-582): 2.58e-22: 103: 14.89
+	Rn
		1351588 Q9QX70_RAT (1-1210): 0: 1241: 90.34		SRC_RAT (287-582): 3.16e-22: 103: 14.56
+	Hs
		338323 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SOS1_HUMAN (26-311): 8.31e-22: 103: 14.15
+	Hs
		337850 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SRC_HUMAN (287-582): 1.42e-21: 100: 14.56
+	Hs
		338983 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SLAP2_HUMAN (399-601): 2.94e-21: 95.9: 22.22
+	Hs
		337875 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MUC1_HUMAN (165-615): 4.13e-17: 88.3: 9.03
+	Hs
		338366 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SLAP1_HUMAN (382-578): 2.29e-16: 82: 17.70
+	Hs
		522997 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		SRC_HUMAN (287-582): 1.42e-21: 100: 14.56
+	Hs
		1071013 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		SLAP2_HUMAN (399-601): 2.94e-21: 95.9: 22.22
+	Rn
		1225226 Q8K3F9_RAT (5-1200): 0: 1129: 48.85		SRC_RAT (287-582): 3.16e-22: 103: 14.56
+	Hs
		554307 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		MUC1_HUMAN (165-615): 4.13e-17: 88.3: 9.03
+	Hs
		1028470 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		SLAP1_HUMAN (382-578): 2.29e-16: 82: 17.70