HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: SH2D3 (Q8N5H7)
SH2 domain-containing protein 3C (Cas/HEF1-associated signal transducer) (Chat-H) (Novel SH2-containing protein 3) (SH2 domain-containing Eph receptor-binding protein 1) (SHEP1)
Gene: SH2D3C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.887

Property	Details
Experiments	25402006, 24658140, 22973453, unassigned2173
Identification Methods	two hybrid, protein complementation assay, pull down, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0032587 - ruffle membrane GO:0033138 - positive regulation of peptidyl-serine phosphorylation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 860
+	Hs
		275521 EGFR_HUMAN (1-1210): 0: 1241: 100.00		BCAR3_HUMAN (55-860): 0: 715: 39.09
+	Mm
		403432 EGFR_MOUSE (1-1210): 0: 1258: 90.35		SRC_MOUSE (20-425): 9.19e-63: 222: 13.68
+	Rn
		1351588 Q9QX70_RAT (1-1210): 0: 1241: 90.34		SRC_RAT (20-425): 1.35e-61: 219: 13.21
+	Hs
		337789 EGFR_HUMAN (1-1210): 0: 1241: 100.00		YES_HUMAN (81-393): 4.07e-61: 218: 11.78
+	Hs
		337850 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SRC_HUMAN (20-393): 2.03e-60: 216: 12.76
+	Hs
		337821 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FGR_HUMAN (112-393): 2.09e-58: 210: 14.29
+	Mm
		957227 EGFR_MOUSE (1-1210): 0: 1258: 90.35		SHC1_MOUSE (95-323): 1.18e-50: 189: 23.28
+	Hs
		337884 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FER_HUMAN (86-569): 1.39e-54: 205: 14.90
+	Hs
		337779 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FES_HUMAN (1-394): 3.67e-54: 204: 18.75
+	Hs
		338084 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FRK_HUMAN (130-394): 2.68e-56: 204: 13.31
+	Hs
		337790 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LYN_HUMAN (132-424): 2.93e-54: 198: 11.39
+	Hs
		337804 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HCK_HUMAN (91-394): 1.07e-53: 197: 13.71
+	Hs
		337769 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LCK_HUMAN (123-424): 1.07e-53: 196: 10.59
+	Rn
		1129188 Q9QX70_RAT (1-1210): 0: 1241: 90.34		SHC1_RAT (8-323): 1.66e-50: 186: 20.06
+	Hs
		337988 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SHC1_HUMAN (97-322): 5.53e-44: 170: 24.02
+	Mm
		964559 EGFR_MOUSE (1-1210): 0: 1258: 90.35		GRB2_MOUSE (214-310): 1.18e-27: 113: 27.00
+	Hs
		337912 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PLCG1_HUMAN (105-427): 7.42e-27: 120: 14.37
+	Rn
		924998 Q9QX70_RAT (1-1210): 0: 1241: 90.34		GRB2_RAT (214-310): 1.18e-27: 113: 27.00
+	Hs
		208970 EGFR_HUMAN (1-1210): 0: 1241: 100.00		NCK2_HUMAN (98-309): 6.4e-23: 103: 18.72
+	Hs
		337978 EGFR_HUMAN (1-1210): 0: 1241: 100.00		P85A_HUMAN (202-319): 6.33e-16: 84.3: 22.58