HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: UBS3B (Q8TF42)
Ubiquitin-associated and SH3 domain-containing protein B (EC 3.1.3.48) (Cbl-interacting protein p70) (Suppressor of T-cell receptor signaling 1) (STS-1) (T-cell ubiquitin ligand 2) (TULA-2) (Tyrosine-protein phosphatase STS1/TULA2)
Gene: UBASH3B

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.968

Property	Details
Experiments	17880946, 24189400, 25754235, 36736316, 15159412, 18271526, 23956138, 24797263, 31585087, 34591642
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 649
+	Hs
		338203 EGFR_HUMAN (1-1210): 0: 1241: 100.00		UBS3A_HUMAN (12-643): 0: 947: 43.37
+	Hs
		383895 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		UBS3B_HUMAN (1-649): 0: 1066: 100.00
+	Mm
		964559 EGFR_MOUSE (1-1210): 0: 1258: 90.35		GRB2_MOUSE (156-319): 3.38e-45: 161: 21.56
+	Hs
		338251 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Rn
		924998 Q9QX70_RAT (1-1210): 0: 1241: 90.34		GRB2_RAT (156-319): 1.37e-45: 163: 21.56
+	Hs
		338817 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SH3K1_HUMAN (221-375): 5.02e-29: 124: 25.00
+	Hs
		298945 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SRBS2_HUMAN (230-317): 1.4e-22: 105: 27.84
+	Hs
		338935 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SRBS1_HUMAN (258-317): 1.89e-18: 92.2: 40.00
+	Hs
		338633 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SH3R1_HUMAN (216-315): 3.02e-18: 91.4: 28.00
+	Hs
		924589 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Hs
		383730 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Hs
		601876 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Hs
		383923 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		SH3K1_HUMAN (221-375): 5.02e-29: 124: 25.00
+	Hs
		434170 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Hs
		872610 EPHB1_HUMAN (640-1071): 8.83e-123: 405: 28.06		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Mm
		872621 EPHB2_MOUSE (640-1067): 7.47e-121: 400: 28.09		GRB2_MOUSE (156-319): 3.38e-45: 161: 21.56
+	Hs
		872630 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Hs
		665574 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Hs
		924590 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Hs
		665643 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		SH3K1_HUMAN (221-375): 5.02e-29: 124: 25.00