HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: SOCS4 (Q8WXH5)
Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7)
Gene: SOCS4

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	0.80	0.609

Property	Details
Experiments	17997974
Identification Methods	unspecified method, isothermal titration calorimetry
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 440
+	Mm
		222646 EGFR_MOUSE (1-1210): 0: 1258: 90.35		SOCS5_MOUSE (7-436): 1.54e-131: 391: 52.26
+	Hs
		256842 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SOCS5_HUMAN (7-436): 2.94e-135: 401: 52.72
+	Mm
		403432 EGFR_MOUSE (1-1210): 0: 1258: 90.35		SRC_MOUSE (139-389): 6.82e-46: 168: 12.74
+	Hs
		337789 EGFR_HUMAN (1-1210): 0: 1241: 100.00		YES_HUMAN (151-429): 7.43e-47: 171: 14.19
+	Rn
		1351588 Q9QX70_RAT (1-1210): 0: 1241: 90.34		SRC_RAT (139-389): 2.14e-45: 166: 12.74
+	Hs
		337850 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SRC_HUMAN (135-389): 2.54e-45: 166: 12.55
+	Hs
		146577 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SOCS2_HUMAN (234-425): 9.62e-47: 161: 25.85
+	Hs
		181754 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SOCS1_HUMAN (260-425): 6.95e-46: 159: 22.29
+	Hs
		337804 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HCK_HUMAN (157-430): 3.66e-42: 158: 15.49
+	Hs
		337821 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FGR_HUMAN (186-433): 4.49e-42: 157: 16.92
+	Hs
		337769 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LCK_HUMAN (195-418): 6.26e-42: 156: 15.88
+	Hs
		338084 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FRK_HUMAN (182-399): 5.9e-41: 154: 16.00
+	Hs
		338331 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ITK_HUMAN (36-419): 2.85e-40: 153: 16.18
+	Hs
		147469 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SOCS6_HUMAN (239-424): 7.84e-40: 151: 32.00
+	Hs
		147370 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SOCS3_HUMAN (250-422): 2.34e-37: 137: 20.09
+	Hs
		338069 EGFR_HUMAN (1-1210): 0: 1241: 100.00		CSK_HUMAN (244-379): 2.34e-33: 132: 18.98
+	Hs
		337886 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PLCG2_HUMAN (258-399): 1.57e-23: 105: 18.88
+	Hs
		337912 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PLCG1_HUMAN (261-379): 1.1e-22: 103: 17.50
+	Hs
		129152 EGFR_HUMAN (1-1210): 0: 1241: 100.00		P85B_HUMAN (231-382): 5.27e-18: 88.7: 20.65
+	Hs
		337978 EGFR_HUMAN (1-1210): 0: 1241: 100.00		P85A_HUMAN (225-392): 2.48e-15: 80.3: 18.71