HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: P55G (Q92569)
Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55-gamma) (PtdIns-3-kinase regulatory subunit p55-gamma) (p55PIK)
Gene: PIK3R3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.918

Property	Details
Experiments	25402006, 24658140, 22973453, 16273093, unassigned2173
Identification Methods	two hybrid, protein complementation assay, pull down, unspecified method, protein array, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0001934 - positive regulation of protein phosphorylation GO:0030335 - positive regulation of cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 461
+	Hs
		337294 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ABL1_HUMAN (3-461): 1.02e-93: 308: 16.12
+	Hs
		337978 EGFR_HUMAN (1-1210): 0: 1241: 100.00		P85A_HUMAN (48-455): 9.1e-92: 295: 79.17
+	Hs
		129152 EGFR_HUMAN (1-1210): 0: 1241: 100.00		P85B_HUMAN (56-453): 2.19e-87: 283: 74.12
+	Hs
		146577 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SOCS2_HUMAN (40-144): 7.17e-30: 117: 28.95
+	Mm
		403432 EGFR_MOUSE (1-1210): 0: 1258: 90.35		SRC_MOUSE (323-459): 7.66e-19: 91.2: 24.14
+	Hs
		338083 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ABL2_HUMAN (324-459): 5.26e-21: 98.5: 25.36
+	Hs
		337769 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LCK_HUMAN (309-458): 5.54e-21: 97.3: 25.95
+	Hs
		337804 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HCK_HUMAN (310-458): 1.43e-19: 93.1: 26.75
+	Hs
		338069 EGFR_HUMAN (1-1210): 0: 1241: 100.00		CSK_HUMAN (357-456): 1.18e-19: 93: 34.65
+	Rn
		1351588 Q9QX70_RAT (1-1210): 0: 1241: 90.34		SRC_RAT (323-459): 5.91e-19: 91.2: 24.14
+	Hs
		337789 EGFR_HUMAN (1-1210): 0: 1241: 100.00		YES_HUMAN (317-459): 6.84e-19: 91.2: 23.72
+	Hs
		337850 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SRC_HUMAN (323-459): 8.26e-19: 90.8: 24.14
+	Hs
		338084 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FRK_HUMAN (256-459): 1.27e-18: 90: 24.04
+	Hs
		337821 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FGR_HUMAN (323-459): 2.54e-18: 89.2: 26.21
+	Hs
		337790 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LYN_HUMAN (298-458): 6.17e-18: 88.1: 24.85
+	Hs
		147469 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SOCS6_HUMAN (47-165): 1.85e-17: 86.8: 31.06
+	Hs
		338080 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MATK_HUMAN (341-456): 1.11e-12: 71.8: 22.22
+	Hs
		337872 EGFR_HUMAN (1-1210): 0: 1241: 100.00		VAV_HUMAN (65-170): 4e-12: 70.6: 27.36
+	Hs
		181754 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SOCS1_HUMAN (46-169): 5.58e-13: 69.8: 23.20
+	Hs
		337886 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PLCG2_HUMAN (337-452): 6.98e-12: 69.8: 33.33