HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: ANS1A (Q92625)
Ankyrin repeat and SAM domain-containing protein 1A (Odin)
Gene: ANKS1A

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.80	0.829

Property	Details
Experiments	25402006, 24658140, 35384245, 16273093, unassigned2173
Identification Methods	two hybrid, protein complementation assay, affinity chromatography technology, proximity labelling technology, unspecified method, protein array, anti tag coimmunoprecipitation, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Ank_2~GF_recep_IV, PK_Tyr_Ser-Thr~SAM_1, Ank_2~Recep_L_domain
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 1134
+	Hs
		1070992 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		ANS1A_HUMAN (1-1134): 0: 792: 100.00
+	Hs
		383908 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		ANS1A_HUMAN (1-1134): 0: 792: 100.00
+	Hs
		338632 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ANS1B_HUMAN (1-1101): 0: 593: 33.52
+	Hs
		1070979 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		ANS1B_HUMAN (1-1101): 0: 593: 33.52
+	Hs
		383867 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		ANS1B_HUMAN (1-1101): 0: 593: 33.52
+	Hs
		339124 EGFR_HUMAN (1-1210): 0: 1241: 100.00		KDIS_HUMAN (121-538): 2.01e-56: 216: 15.20
+	Hs
		338353 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ANK3_HUMAN (183-812): 9.9e-38: 157: 12.04
+	Hs
		338292 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ANK2_HUMAN (180-837): 1.86e-34: 146: 13.55
+	Hs
		602024 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		KDIS_HUMAN (121-538): 2.01e-56: 216: 15.20
+	Mm
		1206693 FAK2_MOUSE (716-974): 4.22e-52: 201: 37.64		ANS1B_MOUSE (1-1133): 0: 621: 33.57
+	Hs
		665635 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		CSKI2_HUMAN (1-592): 3.95e-69: 255: 24.71
+	Hs
		665360 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		KDIS_HUMAN (121-538): 2.01e-56: 216: 15.20
+	Hs
		434233 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		MIB1_HUMAN (3-343): 1.07e-41: 168: 22.32
+	Hs
		665439 EPHA3_HUMAN (654-981): 7.78e-111: 372: 34.51		KDIS_HUMAN (121-538): 2.01e-56: 216: 15.20
+	Hs
		434183 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		ANK3_HUMAN (183-812): 9.9e-38: 157: 12.04
+	Hs
		665280 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		MIB1_HUMAN (3-343): 1.07e-41: 168: 22.32
+	Hs
		665591 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		ANK3_HUMAN (183-812): 9.9e-38: 157: 12.04
+	Hs
		665581 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		ANK2_HUMAN (180-837): 1.86e-34: 146: 13.55
+	Mm
		222869 ACK1_MOUSE (691-967): 2.4e-53: 206: 38.87		ANK2_MOUSE (180-812): 1.69e-33: 143: 13.36
+	Hs
		983635 FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68		ANKH1_HUMAN (2-106): 1.43e-14: 81.3: 23.81