HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: PTPRU (Q92729)
Receptor-type tyrosine-protein phosphatase U (R-PTP-U) (EC 3.1.3.48) (Pancreatic carcinoma phosphatase 2) (PCP-2) (Protein-tyrosine phosphatase J) (PTP-J) (hPTP-J) (Protein-tyrosine phosphatase pi) (PTP pi) (Protein-tyrosine phosphatase receptor omicron) (PTP-RO) (Receptor-type protein-tyrosine phosphatase psi) (R-PTP-psi)
Gene: PTPRU

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	8870675
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Furin-like~fn3, PK_Tyr_Ser-Thr~fn3, PK_Tyr_Ser-Thr~Y_phosphatase, Recep_L_domain~fn3
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 1446
+	Hs
		338458 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRK_HUMAN (26-1442): 0: 1098: 59.48
+	Hs
		337909 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRA_HUMAN (673-1443): 0: 755: 28.46
+	Hs
		337942 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRE_HUMAN (776-1440): 0: 723: 32.15
+	Hs
		337943 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRG_HUMAN (295-1445): 0: 670: 21.71
+	Hs
		383597 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		PTPRA_HUMAN (673-1443): 0: 755: 28.46
+	Hs
		383612 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		PTPRG_HUMAN (295-1445): 0: 670: 21.71
+	Hs
		338349 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRJ_HUMAN (216-1444): 1.65e-118: 405: 14.03
+	Hs
		337831 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRF_HUMAN (7-941): 1.88e-67: 254: 11.64
+	Hs
		337802 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRC_HUMAN (879-1156): 7.53e-63: 238: 26.92
+	Hs
		146919 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRT_HUMAN (17-1145): 2.1e-58: 224: 11.95
+	Hs
		337941 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRD_HUMAN (187-963): 3.95e-39: 162: 10.28
+	Hs
		146927 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		PTPRT_HUMAN (17-1145): 2.1e-58: 224: 11.95
+	Hs
		383545 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		PTPRC_HUMAN (879-1156): 7.53e-63: 238: 26.92
+	Hs
		146920 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		PTPRT_HUMAN (17-1145): 2.1e-58: 224: 11.95
+	Rn
		1143998 ERBB4_RAT (7-1199): 0: 1138: 49.38		PTPRZ_RAT (891-1159): 1.27e-44: 180: 25.00
+	Hs
		339009 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRH_HUMAN (481-885): 1.8e-12: 74.6: 10.58
+	Hs
		337940 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRB_HUMAN (2-813): 4.3e-10: 66.9: 10.42
+	Hs
		383613 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		PTPRZ_HUMAN (891-1159): 2.93e-45: 182: 25.71
+	Hs
		1071017 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		PTPRH_HUMAN (481-885): 1.8e-12: 74.6: 10.58
+	Hs
		383611 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		PTPRB_HUMAN (2-813): 4.3e-10: 66.9: 10.42