HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: LIGO1 (Q96FE5)
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (Leucine-rich repeat and immunoglobulin domain-containing protein 1) (Leucine-rich repeat neuronal protein 1) (Leucine-rich repeat neuronal protein 6A)
Gene: LINGO1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17726113
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	GF_recep_IV~LRR_8, LRR_8~PK_Tyr_Ser-Thr
Common GO terms	GO:0005615 - extracellular space GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 620
+	Mm
		936212 EGFR_MOUSE (1-1210): 0: 1258: 90.35		LRIG1_MOUSE (2-602): 2.98e-101: 333: 14.25
+	Hs
		338841 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LRIG1_HUMAN (2-603): 6.46e-107: 348: 19.30
+	Hs
		299545 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LRIG2_HUMAN (4-620): 5.34e-95: 316: 16.07
+	Hs
		1070999 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		LRIG1_HUMAN (2-603): 6.46e-107: 348: 19.30
+	Hs
		383933 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		LRIG1_HUMAN (2-603): 6.46e-107: 348: 19.30
+	Hs
		601975 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		LRIG1_HUMAN (2-603): 6.46e-107: 348: 19.30
+	Mm
		964570 EGFR_MOUSE (1-1210): 0: 1258: 90.35		LIGO1_MOUSE (1-231): 6.18e-36: 144: 17.87
+	Hs
		338583 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LRIG3_HUMAN (1-218): 1.43e-26: 117: 21.53
+	Hs
		1070977 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		LRIG3_HUMAN (1-218): 1.43e-26: 117: 21.53
+	Hs
		383860 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		LRIG3_HUMAN (1-218): 1.43e-26: 117: 21.53
+	At
		1352201 TMK3_ARATH (346-984): 2.89e-145: 464: 16.13		Y1723_ARATH (25-441): 9.26e-63: 226: 15.59
+	At
		1338064 TMK3_ARATH (346-984): 2.89e-145: 464: 16.13		RGI1_ARATH (49-486): 6.58e-61: 221: 15.42
+	At
		95366 F4I065_ARATH (417-1003): 2.31e-135: 436: 15.92		RGI4_ARATH (1-307): 3.64e-70: 248: 18.98
+	At
		795001 TMK1_ARATH (345-984): 1.18e-139: 449: 15.52		Y1723_ARATH (25-441): 9.26e-63: 226: 15.59
+	At
		83721 Y5182_ARATH (429-1004): 1.84e-136: 439: 14.89		Y3804_ARATH (57-470): 1.61e-64: 231: 17.27
+	At
		85102 F4I065_ARATH (417-1003): 2.31e-135: 436: 15.92		RGI2_ARATH (27-442): 2.85e-58: 213: 16.31
+	At
		83704 Y5182_ARATH (429-1004): 1.84e-136: 439: 14.89		Y4361_ARATH (35-441): 3.74e-56: 207: 15.32
+	At
		84729 F4I065_ARATH (417-1003): 2.31e-135: 436: 15.92		Y4361_ARATH (35-441): 3.74e-56: 207: 15.32
+	At
		84503 TMK3_ARATH (346-984): 2.89e-145: 464: 16.13		GSO1_ARATH (149-445): 4.66e-34: 140: 17.51
+	At
		84463 TMK1_ARATH (345-984): 1.18e-139: 449: 15.52		GSO1_ARATH (149-445): 4.66e-34: 140: 17.51