HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: Q9BPW0 (Q9BPW0)
Serine/threonine-protein phosphatase (EC 3.1.3.16)
Gene: PPP5C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	25036637
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 484
+	Hs
		338171 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PPP5_HUMAN (1-482): 0: 546: 99.17
+	Mm
		926535 EGFR_MOUSE (1-1210): 0: 1258: 90.35		PP1G_MOUSE (195-481): 1.75e-152: 438: 37.85
+	Hs
		338242 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PP2AB_HUMAN (190-483): 3.71e-154: 442: 39.32
+	Hs
		383952 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		Q9BPW0_HUMAN (1-484): 0: 546: 100.00
+	Hs
		383734 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		PP2AA_HUMAN (188-483): 3.01e-169: 480: 40.33
+	Hs
		383725 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		PP2AB_HUMAN (190-483): 3.71e-154: 442: 39.32
+	Mm
		930629 EPHA5_MOUSE (510-1061): 3.23e-120: 395: 22.77		PP2AA_MOUSE (188-483): 3.95e-169: 480: 40.33
+	Dm
		1096401 SHARK_DROME (691-975): 7.21e-53: 203: 39.52		Q9VH81_DROME (2-482): 1.01e-173: 500: 59.79
+	Hs
		796542 KSYK_HUMAN (716-961): 1.13e-53: 201: 41.70		PP2AA_HUMAN (188-483): 3.01e-169: 480: 40.33
+	Hs
		906422 FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68		PP1B_HUMAN (194-482): 2.2e-153: 441: 36.90
+	Mm
		710129 FAK1_MOUSE (716-991): 5.99e-54: 207: 37.68		PP1A_MOUSE (196-479): 1.86e-152: 438: 38.25
+	Hs
		905847 FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68		PP1A_HUMAN (196-479): 3.63e-152: 438: 38.25
+	Hs
		796535 KSYK_HUMAN (716-961): 1.13e-53: 201: 41.70		PP1A_HUMAN (196-479): 3.63e-152: 438: 38.25