HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: AP1M1 (Q9BXS5)
AP-1 complex subunit mu-1 (AP-mu chain family member mu1A) (Adaptor protein complex AP-1 subunit mu-1) (Adaptor-related protein complex 1 subunit mu-1) (Clathrin assembly protein complex 1 mu-1 medium chain 1) (Clathrin coat assembly protein AP47) (Clathrin coat-associated protein AP47) (Golgi adaptor HA1/AP1 adaptin mu-1 subunit) (Mu-adaptin 1) (Mu1A-adaptin)
Gene: AP1M1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	23956138, 24797263
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000139 - Golgi membrane GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 423
+	Hs
		339212 EGFR_HUMAN (1-1210): 0: 1241: 100.00		AP1M2_HUMAN (1-422): 1.39e-177: 503: 79.86
+	Hs
		338822 EGFR_HUMAN (1-1210): 0: 1241: 100.00		AP2M1_HUMAN (3-421): 3.27e-155: 447: 38.85
+	Hs
		339173 EGFR_HUMAN (1-1210): 0: 1241: 100.00		AP3M1_HUMAN (3-422): 5.32e-127: 375: 26.73
+	Hs
		384056 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		AP1M2_HUMAN (1-422): 1.39e-177: 503: 79.86
+	Hs
		602043 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		AP1M2_HUMAN (1-422): 1.39e-177: 503: 79.86
+	Rn
		544829 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		AP1M1_RAT (1-423): 0: 527: 99.53
+	Hs
		665310 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		AP2M1_HUMAN (3-421): 3.27e-155: 447: 38.85
+	Rn
		544815 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		AP2M1_RAT (3-421): 3.27e-155: 447: 38.85
+	Hs
		983696 FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68		AP3M1_HUMAN (3-422): 5.32e-127: 375: 26.73
+	Hs
		818944 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		COPD_HUMAN (8-165): 1.23e-18: 89.7: 17.72
+	Hs
		411333 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		COPD_HUMAN (8-165): 1.23e-18: 89.7: 17.72
+	Rn
		1146015 T2CB11_RAT (484-1032): 2.14e-107: 371: 21.03		COPD_RAT (8-165): 1.37e-18: 89.7: 17.72
+	Rn
		544885 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		COPD_RAT (8-165): 1.37e-18: 89.7: 17.72
+	Gg
		94480 KSYK_CHICK (718-961): 1.71e-55: 206: 41.30		COPD_CHICK (1-165): 1.21e-40: 152: 18.18