HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: ILKAP (Q9H0C8)
Integrin-linked kinase-associated serine/threonine phosphatase 2C (ILKAP) (EC 3.1.3.16)
Gene: ILKAP

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	28065597
Identification Methods	two hybrid, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0090263 - positive regulation of canonical Wnt signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 392
+	Hs
		1071009 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		ILKAP_HUMAN (1-392): 3.77e-141: 408: 100.00
+	Hs
		338040 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PPM1A_HUMAN (89-390): 1.79e-98: 299: 28.44
+	Hs
		273334 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PPM1B_HUMAN (89-390): 3.85e-93: 289: 27.13
+	Hs
		383969 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		ILKAP_HUMAN (1-392): 3.77e-141: 408: 100.00
+	Hs
		338124 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PPM1F_HUMAN (8-391): 7.42e-87: 272: 26.57
+	Hs
		601994 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		ILKAP_HUMAN (1-392): 3.77e-141: 408: 100.00
+	Hs
		728610 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		PPM1A_HUMAN (89-390): 1.79e-98: 299: 28.44
+	Hs
		273436 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		PPM1B_HUMAN (89-390): 3.85e-93: 289: 27.13
+	Hs
		383653 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		PPM1A_HUMAN (89-390): 1.79e-98: 299: 28.44
+	Hs
		829448 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		PPM1F_HUMAN (8-391): 7.42e-87: 272: 26.57
+	Hs
		383693 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		PPM1F_HUMAN (8-391): 7.42e-87: 272: 26.57
+	Hs
		601827 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		PPM1A_HUMAN (89-390): 1.79e-98: 299: 28.44
+	Hs
		273365 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		PPM1B_HUMAN (89-390): 3.85e-93: 289: 27.13
+	Hs
		601851 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		PPM1F_HUMAN (8-391): 7.42e-87: 272: 26.57
+	Hs
		601946 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		PPM1K_HUMAN (139-391): 7.66e-27: 111: 32.06
+	Hs
		665328 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		ILKAP_HUMAN (1-392): 3.77e-141: 408: 100.00
+	Hs
		665159 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		PPM1A_HUMAN (89-390): 1.79e-98: 299: 28.44
+	Hs
		411324 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		PPM1A_HUMAN (89-390): 1.79e-98: 299: 28.44
+	Hs
		665259 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		PPM1L_HUMAN (56-391): 8.21e-88: 271: 27.70
+	Hs
		411335 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		PPM1F_HUMAN (8-391): 7.42e-87: 272: 26.57