HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: TARA (Q9H2D6)
TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin)
Gene: TRIOBP

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005925 - focal adhesion GO:0031625 - ubiquitin protein ligase binding GO:0051015 - actin filament binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 2365
+	Hs
		338878 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MUC4_HUMAN (2-1637): 1.14e-59: 231: 9.50
+	Hs
		338585 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MPRIP_HUMAN (1554-2357): 2.27e-56: 217: 33.82
+	Hs
		254427 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ROCK2_HUMAN (1806-2363): 5.22e-37: 156: 12.52
+	Hs
		1071005 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		MUC4_HUMAN (2-1637): 1.14e-59: 231: 9.50
+	Hs
		338037 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MYH9_HUMAN (1312-2225): 5.12e-28: 126: 8.32
+	Hs
		383946 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		MUC4_HUMAN (2-1637): 1.14e-59: 231: 9.50
+	Hs
		601984 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		MUC4_HUMAN (2-1637): 1.14e-59: 231: 9.50
+	Hs
		338292 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ANK2_HUMAN (28-1012): 2.01e-09: 65.7: 14.82
+	Hs
		338765 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MUC16_HUMAN (133-1005): 3.27e-09: 64.9: 13.81
+	Hs
		665271 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		MPRIP_HUMAN (1554-2357): 2.27e-56: 217: 33.82
+	Hs
		665375 EPHA3_HUMAN (654-981): 7.78e-111: 372: 34.51		MYH9_HUMAN (1312-2225): 5.12e-28: 126: 8.32
+	Hs
		1189813 EPHA6_HUMAN (629-1016): 8.37e-118: 393: 27.80		MYH14_HUMAN (2035-2363): 1.9e-15: 85.4: 15.06
+	Hs
		665581 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		ANK2_HUMAN (28-1012): 2.01e-09: 65.7: 14.82
+	Dm
		1001998 Q0KIF4_DROME (621-1017): 1.89e-113: 382: 32.07		Q9VLS7_DROME (138-844): 3.51e-09: 64.9: 14.37
+	Mm
		222828 ACK1_MOUSE (691-967): 2.4e-53: 206: 38.87		MPRIP_MOUSE (1554-2357): 2.97e-53: 207: 32.49
+	Mm
		222845 ACK1_MOUSE (691-967): 2.4e-53: 206: 38.87		MYH10_MOUSE (1532-2330): 1.9e-35: 151: 10.53
+	Mm
		222875 ACK1_MOUSE (691-967): 2.4e-53: 206: 38.87		MYH9_MOUSE (1813-2365): 4.87e-30: 133: 12.21
+	Mm
		222869 ACK1_MOUSE (691-967): 2.4e-53: 206: 38.87		ANK2_MOUSE (61-1013): 1.59e-12: 75.7: 15.18