HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: PEAK1 (Q9H792)
Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269)
Gene: PEAK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0005925 - focal adhesion GO:0046777 - protein autophosphorylation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 1746
+	Hs
		434286 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		665659 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		1072599 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		665432 EPHA3_HUMAN (654-981): 7.78e-111: 372: 34.51		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Rn
		88928 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		D4A563_RAT (1-1746): 0: 2074: 85.98
+	Hs
		435763 IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		338299 EGFR_HUMAN (1-1210): 0: 1241: 100.00		KPCE_HUMAN (1354-1719): 3.19e-92: 318: 13.98
+	Hs
		338004 EGFR_HUMAN (1-1210): 0: 1241: 100.00		AKT1_HUMAN (1362-1695): 4.43e-91: 307: 15.07
+	Hs
		337895 EGFR_HUMAN (1-1210): 0: 1241: 100.00		KAPCA_HUMAN (1345-1709): 1.06e-90: 301: 18.30
+	Hs
		383640 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		AKT1_HUMAN (1362-1695): 4.43e-91: 307: 15.07
+	Hs
		601822 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		AKT1_HUMAN (1362-1695): 4.43e-91: 307: 15.07
+	Hs
		568539 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		KAPCA_HUMAN (1345-1709): 1.06e-90: 301: 18.30
+	Hs
		338596 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PEAK3_HUMAN (1653-1743): 1.22e-30: 129: 38.46
+	Hs
		872666 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		KCC1B_HUMAN (1379-1736): 2.78e-92: 305: 13.97
+	Hs
		665151 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		AKT1_HUMAN (1362-1695): 4.43e-91: 307: 15.07
+	Hs
		568557 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		KAPCA_HUMAN (1345-1709): 1.06e-90: 301: 18.30
+	Hs
		681809 ACK1_HUMAN (691-967): 4.54e-56: 214: 39.58		AKT1_HUMAN (1362-1695): 4.43e-91: 307: 15.07
+	Mm
		554948 FAK2_MOUSE (716-974): 4.22e-52: 201: 37.64		KPCE_MOUSE (1352-1719): 4.36e-92: 318: 13.12
+	Hs
		435552 IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47		AKT1_HUMAN (1362-1695): 4.43e-91: 307: 15.07
+	Hs
		616681 KSYK_HUMAN (716-961): 1.13e-53: 201: 41.70		KS6B1_HUMAN (1453-1683): 8.42e-45: 173: 16.17