HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: WDR6 (Q9NNW5)
tRNA (34-2'-O)-methyltransferase regulator WDR6 (WD repeat-containing protein 6)
Gene: WDR6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	24797263, 25754235, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 1121
+	Hs
		383990 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		WDR6_HUMAN (1-1121): 0: 745: 100.00
+	Hs
		338260 EGFR_HUMAN (1-1210): 0: 1241: 100.00		RACK1_HUMAN (196-523): 2.91e-47: 173: 17.21
+	Hs
		338591 EGFR_HUMAN (1-1210): 0: 1241: 100.00		EMAL6_HUMAN (2-236): 7.3e-13: 75.5: 10.86
+	Hs
		338342 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TBL3_HUMAN (12-118): 1.81e-11: 70.5: 7.34
+	Hs
		383733 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		RACK1_HUMAN (196-523): 2.91e-47: 173: 17.21
+	Hs
		384037 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		FBW1A_HUMAN (30-284): 7.71e-34: 140: 13.41
+	Hs
		383918 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		FBXW7_HUMAN (603-914): 3.98e-13: 76: 13.75
+	Hs
		872714 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		WDR6_HUMAN (1-1121): 0: 745: 100.00
+	Hs
		1072605 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		WDR6_HUMAN (1-1121): 0: 745: 100.00
+	Hs
		665339 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		WDR6_HUMAN (1-1121): 0: 745: 100.00
+	Hs
		411502 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		WDR6_HUMAN (1-1121): 0: 745: 100.00
+	Hs
		665435 EPHA3_HUMAN (654-981): 7.78e-111: 372: 34.51		WDR6_HUMAN (1-1121): 0: 745: 100.00
+	Hs
		411353 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		RACK1_HUMAN (196-523): 2.91e-47: 173: 17.21
+	Rn
		88690 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		D3ZQR6_RAT (490-1072): 3.41e-18: 93.2: 9.55
+	Gg
		94456 KSYK_CHICK (718-961): 1.71e-55: 206: 41.30		RACK1_CHICK (196-523): 2.91e-47: 173: 17.21
+	Hs
		796541 KSYK_HUMAN (716-961): 1.13e-53: 201: 41.70		RACK1_HUMAN (196-523): 2.91e-47: 173: 17.21
+	Hs
		435605 IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47		RACK1_HUMAN (196-523): 2.91e-47: 173: 17.21