HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: SH22A (Q9NP31)
SH2 domain-containing protein 2A (SH2 domain-containing adapter protein) (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein)
Gene: SH2D2A

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	22973453, 16273093
Identification Methods	pull down, unspecified method, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005737 - cytoplasm GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 389
+	Mm
		403432 EGFR_MOUSE (1-1210): 0: 1258: 90.35		SRC_MOUSE (4-280): 1.66e-51: 182: 17.73
+	Mm
		964559 EGFR_MOUSE (1-1210): 0: 1258: 90.35		GRB2_MOUSE (56-256): 2.26e-50: 170: 15.71
+	Rn
		1351588 Q9QX70_RAT (1-1210): 0: 1241: 90.34		SRC_RAT (5-280): 5.38e-50: 177: 17.45
+	Hs
		337872 EGFR_HUMAN (1-1210): 0: 1241: 100.00		VAV_HUMAN (6-256): 4.43e-48: 176: 15.77
+	Hs
		337821 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FGR_HUMAN (6-258): 5.75e-49: 175: 15.64
+	Hs
		337850 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SRC_HUMAN (21-280): 1.14e-48: 174: 17.73
+	Hs
		337790 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LYN_HUMAN (9-313): 7.12e-48: 171: 14.82
+	Hs
		338167 EGFR_HUMAN (1-1210): 0: 1241: 100.00		VAV2_HUMAN (6-258): 3.29e-46: 171: 13.22
+	Hs
		338102 EGFR_HUMAN (1-1210): 0: 1241: 100.00		CRKL_HUMAN (95-347): 5.6e-49: 169: 21.76
+	Hs
		338251 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GRB2_HUMAN (56-256): 4.42e-50: 169: 15.71
+	Rn
		924998 Q9QX70_RAT (1-1210): 0: 1241: 90.34		GRB2_RAT (56-256): 4.42e-50: 169: 15.71
+	Hs
		337789 EGFR_HUMAN (1-1210): 0: 1241: 100.00		YES_HUMAN (7-280): 2.56e-46: 168: 16.56
+	Hs
		337804 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HCK_HUMAN (6-212): 2.97e-45: 165: 15.93
+	Hs
		337769 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LCK_HUMAN (22-210): 4.42e-45: 164: 17.31
+	Hs
		338101 EGFR_HUMAN (1-1210): 0: 1241: 100.00		CRK_HUMAN (95-341): 6.51e-46: 161: 17.28
+	Hs
		275158 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GRAP2_HUMAN (68-220): 2.23e-45: 160: 21.66
+	Hs
		338406 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTK6_HUMAN (84-194): 4.58e-32: 127: 28.93
+	Hs
		338084 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FRK_HUMAN (84-210): 2.03e-24: 106: 24.11
+	Hs
		338093 EGFR_HUMAN (1-1210): 0: 1241: 100.00		KSYK_HUMAN (94-213): 1.09e-17: 86.9: 23.81
+	Hs
		338092 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ZAP70_HUMAN (86-222): 1.53e-17: 86.1: 20.98