HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: ABI2 (Q9NYB9)
Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1)
Gene: ABI2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0018108 - peptidyl-tyrosine phosphorylation GO:0019900 - kinase binding GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 513
+	Hs
		338681 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ABI1_HUMAN (1-513): 3.84e-97: 304: 61.00
+	Mm
		654977 EGFR_MOUSE (1-1210): 0: 1258: 90.35		VAV_MOUSE (299-513): 2.22e-27: 118: 19.30
+	Hs
		337872 EGFR_HUMAN (1-1210): 0: 1241: 100.00		VAV_HUMAN (276-513): 8.6e-32: 131: 17.86
+	Hs
		338425 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SRC8_HUMAN (271-507): 2.78e-32: 131: 17.84
+	Hs
		338823 EGFR_HUMAN (1-1210): 0: 1241: 100.00		Q96D37_HUMAN (276-513): 7.97e-32: 131: 17.86
+	Hs
		339121 EGFR_HUMAN (1-1210): 0: 1241: 100.00		VAV3_HUMAN (259-507): 4.72e-30: 126: 14.07
+	Mm
		964571 EGFR_MOUSE (1-1210): 0: 1258: 90.35		ARHG7_MOUSE (451-508): 1.08e-17: 88.5: 43.10
+	Mm
		964559 EGFR_MOUSE (1-1210): 0: 1258: 90.35		GRB2_MOUSE (454-510): 7.13e-18: 84.5: 37.93
+	Hs
		338419 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ARHG7_HUMAN (451-508): 2.16e-18: 90.8: 41.38
+	Hs
		298945 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SRBS2_HUMAN (373-509): 1.11e-16: 85.5: 19.87
+	Hs
		338251 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GRB2_HUMAN (454-510): 7.13e-18: 84.5: 37.93
+	Rn
		924998 Q9QX70_RAT (1-1210): 0: 1241: 90.34		GRB2_RAT (454-510): 7.13e-18: 84.5: 37.93
+	Hs
		339058 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ITSN2_HUMAN (289-512): 5.53e-14: 77.2: 15.63
+	Hs
		338478 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ITSN1_HUMAN (380-510): 4.82e-12: 71: 15.22
+	Hs
		548711 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		VAV_HUMAN (276-513): 8.6e-32: 131: 17.86
+	Hs
		1071026 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		VAV3_HUMAN (259-507): 4.72e-30: 126: 14.07
+	Hs
		383580 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		VAV_HUMAN (276-513): 8.6e-32: 131: 17.86
+	Hs
		383927 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		Q96D37_HUMAN (276-513): 7.97e-32: 131: 17.86
+	Hs
		924589 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		GRB2_HUMAN (454-510): 7.13e-18: 84.5: 37.93
+	Hs
		383730 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		GRB2_HUMAN (454-510): 7.13e-18: 84.5: 37.93