Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR
Interactor 2: HDAC6 (Q9UBN7)
Histone deacetylase 6 (HD6) (EC 3.5.1.98) (Protein deacetylase HDAC6) (EC 3.5.1.-) (Tubulin-lysine deacetylase HDAC6) (EC 3.5.1.-)
Gene: HDAC6
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.92 | 0.60 | 0.744 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 25402006, 24658140, 20133936, 20029029, 35676659, unassigned2173 |
| Identification Methods | two hybrid, protein complementation assay, affinity chromatography technology, protein kinase assay, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, ubiquitin reconstruction |
| Interaction Type | direct interaction, physical association, phosphorylation reaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0019899 - enzyme binding GO:0031625 - ubiquitin protein ligase binding GO:0033138 - positive regulation of peptidyl-serine phosphorylation and 2 others more... |
| Homologous interactions | 15 |
Homologous interactions
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
