HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: SE1L1 (Q9UBV2)
Protein sel-1 homolog 1 (Suppressor of lin-12-like protein 1) (Sel-1L)
Gene: SEL1L

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35384245, 23956138
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005789 - endoplasmic reticulum membrane
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 794
+	Hs
		337733 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FINC_HUMAN (60-318): 1.27e-46: 182: 22.06
+	Hs
		434303 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		SE1L1_HUMAN (1-794): 0: 752: 100.00
+	Hs
		411516 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		SE1L1_HUMAN (1-794): 0: 752: 100.00
+	Hs
		435791 IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47		SE1L1_HUMAN (1-794): 0: 752: 100.00
+	Rn
		392799 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		FINC_RAT (60-318): 9.03e-45: 177: 21.69
+	Rn
		88565 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		D3ZD31_RAT (82-212): 1.71e-32: 138: 31.30
+	Rn
		88726 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		FA12_RAT (113-168): 5.32e-18: 90.2: 35.71