HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: GGA2 (Q9UJY4)
ADP-ribosylation factor-binding protein GGA2 (Gamma-adaptin-related protein 2) (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear)
Gene: GGA2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	29358589, 30578931
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0010008 - endosome membrane GO:0031901 - early endosome membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 613
+	Hs
		339110 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GGA1_HUMAN (19-612): 1.68e-159: 473: 44.67
+	Hs
		212580 EGFR_HUMAN (1-1210): 0: 1241: 100.00		AP1G1_HUMAN (44-610): 7.48e-109: 347: 17.44
+	Hs
		276982 EGFR_HUMAN (1-1210): 0: 1241: 100.00		STAM2_HUMAN (19-521): 4.17e-99: 313: 17.66
+	Hs
		272785 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TM1L1_HUMAN (23-494): 3.31e-86: 278: 18.01
+	Hs
		339057 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GGA3_HUMAN (328-611): 1.6e-47: 179: 32.33
+	Hs
		276351 EGFR_HUMAN (1-1210): 0: 1241: 100.00		AP1G2_HUMAN (426-610): 9.51e-40: 157: 25.41
+	Hs
		276988 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		STAM2_HUMAN (19-521): 4.17e-99: 313: 17.66
+	Rn
		71352 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		B2RYN6_RAT (44-610): 2.62e-108: 346: 17.61
+	Hs
		277037 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		STAM2_HUMAN (19-521): 4.17e-99: 313: 17.66
+	Hs
		277152 EPHA6_HUMAN (629-1016): 8.37e-118: 393: 27.80		STAM2_HUMAN (19-521): 4.17e-99: 313: 17.66
+	Hs
		277067 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		STAM2_HUMAN (19-521): 4.17e-99: 313: 17.66
+	Hs
		277010 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		STAM2_HUMAN (19-521): 4.17e-99: 313: 17.66
+	Hs
		665303 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		STAM1_HUMAN (19-524): 3.22e-96: 306: 15.76
+	Hs
		277011 EPHA3_HUMAN (654-981): 7.78e-111: 372: 34.51		STAM2_HUMAN (19-521): 4.17e-99: 313: 17.66
+	Rn
		78228 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		B5DFM1_RAT (23-494): 5.86e-80: 262: 17.81
+	Hs
		434297 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		GGA3_HUMAN (328-611): 1.6e-47: 179: 32.33
+	Hs
		665436 EPHA3_HUMAN (654-981): 7.78e-111: 372: 34.51		GGA3_HUMAN (328-611): 1.6e-47: 179: 32.33
+	Hs
		435783 IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47		GGA3_HUMAN (328-611): 1.6e-47: 179: 32.33