HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: VAV3 (Q9UKW4)
Guanine nucleotide exchange factor VAV3 (VAV-3)
Gene: VAV3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.931

Property	Details
Experiments	10938113, 24797263, 25754235, 22973453, 36736316, 31585087
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	C1_1~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 847
+	Mm
		654977 EGFR_MOUSE (1-1210): 0: 1258: 90.35		VAV_MOUSE (1-846): 0: 600: 57.90
+	Hs
		337872 EGFR_HUMAN (1-1210): 0: 1241: 100.00		VAV_HUMAN (1-846): 0: 609: 57.31
+	Hs
		338167 EGFR_HUMAN (1-1210): 0: 1241: 100.00		VAV2_HUMAN (1-846): 0: 574: 50.00
+	Hs
		1071026 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		VAV3_HUMAN (1-847): 0: 663: 100.00
+	Hs
		338823 EGFR_HUMAN (1-1210): 0: 1241: 100.00		Q96D37_HUMAN (69-846): 0: 546: 55.77
+	Hs
		548711 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		VAV_HUMAN (1-846): 0: 609: 57.31
+	Hs
		855797 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		VAV2_HUMAN (1-846): 0: 574: 50.00
+	Mm
		964564 EGFR_MOUSE (1-1210): 0: 1258: 90.35		FGD5_MOUSE (1-601): 4e-77: 274: 11.65
+	Hs
		338594 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FGD5_HUMAN (1-614): 5.83e-77: 275: 13.26
+	Hs
		224717 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		KALRN_HUMAN (152-705): 9.15e-54: 205: 14.14
+	Mm
		964571 EGFR_MOUSE (1-1210): 0: 1258: 90.35		ARHG7_MOUSE (747-847): 1.35e-14: 80.2: 27.72
+	Mm
		964559 EGFR_MOUSE (1-1210): 0: 1258: 90.35		GRB2_MOUSE (793-844): 2.65e-11: 65.9: 40.39
+	Hs
		337886 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PLCG2_HUMAN (661-845): 3.61e-15: 82.4: 32.18
+	Hs
		338419 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ARHG7_HUMAN (747-847): 4.63e-15: 81.8: 27.72
+	Hs
		337912 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PLCG1_HUMAN (661-845): 1.02e-14: 80.9: 30.35
+	Hs
		338251 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Rn
		924998 Q9QX70_RAT (1-1210): 0: 1241: 90.34		GRB2_RAT (793-844): 2.55e-11: 65.9: 40.39
+	Hs
		562648 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		PLCG2_HUMAN (661-845): 3.61e-15: 82.4: 32.18
+	Hs
		581010 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		PLCG1_HUMAN (661-845): 1.02e-14: 80.9: 30.35
+	Hs
		924589 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39