HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: KDIS (Q9ULH0)
Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein)
Gene: KIDINS220

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~GF_recep_IV, Ank_2~Recep_L_domain
Common GO terms	GO:0016020 - membrane GO:0032991 - protein-containing complex
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 1771
+	Hs
		602024 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		KDIS_HUMAN (13-1771): 0: 2634: 100.00
+	Hs
		665360 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		KDIS_HUMAN (13-1771): 0: 2634: 100.00
+	Hs
		665439 EPHA3_HUMAN (654-981): 7.78e-111: 372: 34.51		KDIS_HUMAN (13-1771): 0: 2634: 100.00
+	Hs
		338353 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ANK3_HUMAN (206-542): 1.55e-67: 256: 18.50
+	Hs
		338292 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ANK2_HUMAN (3-233): 5.93e-53: 208: 25.11
+	Hs
		434183 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		ANK3_HUMAN (206-542): 1.55e-67: 256: 18.50
+	Hs
		665591 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		ANK3_HUMAN (206-542): 1.55e-67: 256: 18.50
+	Hs
		665581 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		ANK2_HUMAN (3-233): 5.93e-53: 208: 25.11
+	Mm
		222869 ACK1_MOUSE (691-967): 2.4e-53: 206: 38.87		ANK2_MOUSE (3-228): 3.65e-52: 206: 25.22
+	Hs
		796462 ZAP70_HUMAN (718-961): 5.57e-53: 199: 39.59		DAPK1_HUMAN (4-305): 4.92e-35: 149: 31.58
+	Hs
		983635 FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68		ANKH1_HUMAN (359-505): 5.6e-23: 109: 12.16