HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: BAIP2 (Q9UQB8)
BAR/IMD domain-containing adapter protein 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2) (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53)
Gene: BAIAP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.718

Property	Details
Experiments	25402006, 24658140, 24189400, 35384245, unassigned2173
Identification Methods	two hybrid, protein complementation assay, affinity chromatography technology, proximity labelling technology, ubiquitin reconstruction, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0071364 - cellular response to epidermal growth factor stimulus
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 552
+	Hs
		339097 EGFR_HUMAN (1-1210): 0: 1241: 100.00		BI2L1_HUMAN (3-529): 1.57e-106: 330: 39.85
+	Hs
		339132 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PACN2_HUMAN (3-436): 4.17e-62: 213: 15.61
+	Hs
		338405 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SPTN1_HUMAN (3-442): 2.09e-42: 165: 11.85
+	Hs
		339058 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ITSN2_HUMAN (166-444): 7.54e-12: 70.6: 14.13
+	Hs
		338478 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ITSN1_HUMAN (268-455): 5.42e-10: 64.5: 15.18
+	Hs
		434313 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		BAIP2_HUMAN (1-552): 7.45e-143: 425: 100.00
+	Hs
		872731 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		BAIP2_HUMAN (1-552): 7.45e-143: 425: 100.00
+	Hs
		665684 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		BAIP2_HUMAN (1-552): 7.45e-143: 425: 100.00
+	Hs
		1072630 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		BAIP2_HUMAN (1-552): 7.45e-143: 425: 100.00
+	Hs
		872725 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		BI2L1_HUMAN (3-529): 1.57e-106: 330: 39.85
+	Hs
		665679 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		BI2L1_HUMAN (3-529): 1.57e-106: 330: 39.85
+	Hs
		1072622 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		BI2L1_HUMAN (3-529): 1.57e-106: 330: 39.85
+	Rn
		544832 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		BI2L1_RAT (3-529): 5.67e-102: 319: 38.39
+	Hs
		872730 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		PACN2_HUMAN (3-436): 4.17e-62: 213: 15.61
+	Hs
		665683 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		PACN2_HUMAN (3-436): 4.17e-62: 213: 15.61
+	Hs
		1072628 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		PACN2_HUMAN (3-436): 4.17e-62: 213: 15.61
+	Hs
		1072529 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		MTSS2_HUMAN (19-388): 2.46e-43: 166: 16.45
+	Hs
		665608 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		ITSN1_HUMAN (268-455): 5.42e-10: 64.5: 15.18