HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: IRS2 (Q9Y4H2)
Insulin receptor substrate 2 (IRS-2)
Gene: IRS2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	18271526
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0008284 - positive regulation of cell population proliferation GO:0019903 - protein phosphatase binding GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 1338
+	Hs
		338036 EGFR_HUMAN (1-1210): 0: 1241: 100.00		IRS1_HUMAN (21-1195): 9.72e-82: 296: 32.47
+	Hs
		151678 EGFR_HUMAN (1-1210): 0: 1241: 100.00		IRS4_HUMAN (26-1066): 1.14e-74: 274: 21.72
+	Hs
		383652 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		IRS1_HUMAN (21-1195): 9.72e-82: 296: 32.47
+	Hs
		337875 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MUC1_HUMAN (289-926): 1.69e-34: 146: 14.46
+	Hs
		151685 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		IRS4_HUMAN (26-1066): 1.14e-74: 274: 21.72
+	Hs
		338878 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MUC4_HUMAN (309-1323): 1.13e-13: 78.8: 10.22
+	Hs
		554307 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		MUC1_HUMAN (289-926): 1.69e-34: 146: 14.46
+	Hs
		383583 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		MUC1_HUMAN (289-926): 1.69e-34: 146: 14.46
+	Hs
		554266 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		MUC1_HUMAN (289-926): 1.69e-34: 146: 14.46
+	Hs
		1071005 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		MUC4_HUMAN (309-1323): 1.13e-13: 78.8: 10.22
+	Hs
		383946 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		MUC4_HUMAN (309-1323): 1.13e-13: 78.8: 10.22
+	Hs
		384010 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		DAPLE_HUMAN (303-786): 4.42e-09: 63.4: 12.02
+	Hs
		601984 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		MUC4_HUMAN (309-1323): 1.13e-13: 78.8: 10.22
+	Hs
		411534 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		IRS2_HUMAN (1-1338): 1.35e-161: 522: 100.00
+	Mm
		724601 IGF1R_MOUSE (464-1068): 2.92e-112: 384: 19.65		IRS1_MOUSE (21-1164): 5.96e-79: 287: 32.74
+	Hs
		411322 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		IRS1_HUMAN (21-1195): 9.72e-82: 296: 32.47
+	Mm
		546265 INSR_MOUSE (428-1032): 4.47e-109: 375: 19.65		IRS1_MOUSE (21-1164): 5.96e-79: 287: 32.74
+	Mm
		724595 EPHA2_MOUSE (683-1016): 1.02e-111: 375: 33.82		IRS1_MOUSE (21-1164): 5.96e-79: 287: 32.74
+	Dm
		1001998 Q0KIF4_DROME (621-1017): 1.89e-113: 382: 32.07		Q9VLS7_DROME (276-1207): 2.09e-13: 77.6: 8.59
+	Rn
		88517 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		D3ZAP7_RAT (523-1176): 1.07e-10: 68.7: 13.31