HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: M4K5 (Q9Y4K4)
Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (Kinase homologous to SPS1/STE20) (KHS) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5)
Gene: MAP4K5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	25754235, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 846
+	Hs
		338799 EGFR_HUMAN (1-1210): 0: 1241: 100.00		M4K1_HUMAN (9-845): 0: 774: 44.52
+	Hs
		338005 EGFR_HUMAN (1-1210): 0: 1241: 100.00		AKT2_HUMAN (1-350): 8.02e-130: 398: 22.63
+	Hs
		338610 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MARK2_HUMAN (2-473): 3.58e-124: 394: 21.36
+	Hs
		338004 EGFR_HUMAN (1-1210): 0: 1241: 100.00		AKT1_HUMAN (12-346): 6.18e-125: 386: 22.38
+	Hs
		339069 EGFR_HUMAN (1-1210): 0: 1241: 100.00		STK26_HUMAN (7-302): 4.07e-119: 368: 43.43
+	Hs
		601911 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		KCC2D_HUMAN (8-517): 1.77e-144: 437: 18.38
+	Hs
		339116 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TNIK_HUMAN (14-295): 1.26e-72: 262: 45.73
+	Hs
		383640 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		AKT1_HUMAN (12-346): 6.18e-125: 386: 22.38
+	Hs
		384054 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		STK24_HUMAN (8-379): 1.48e-118: 368: 37.53
+	Hs
		324708 EGFR_HUMAN (1-1210): 0: 1241: 100.00		M4K4_HUMAN (2-295): 4.04e-64: 236: 43.51
+	Hs
		601822 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		AKT1_HUMAN (12-346): 6.18e-125: 386: 22.38
+	Hs
		1072635 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		M4K5_HUMAN (1-846): 0: 1037: 100.00
+	Hs
		434225 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		MARK2_HUMAN (2-473): 3.58e-124: 394: 21.36
+	Hs
		647831 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		MARK3_HUMAN (13-559): 3.08e-135: 422: 18.71
+	Hs
		665680 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		TNIK_HUMAN (14-295): 1.26e-72: 262: 45.73
+	Hs
		1072625 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		TNIK_HUMAN (14-295): 1.26e-72: 262: 45.73
+	Hs
		1072547 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		MINK1_HUMAN (3-295): 3.13e-70: 254: 45.28
+	Hs
		324762 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		M4K4_HUMAN (2-295): 4.04e-64: 236: 43.51
+	Hs
		324742 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		M4K4_HUMAN (2-295): 4.04e-64: 236: 43.51
+	Hs
		324809 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		M4K4_HUMAN (2-295): 4.04e-64: 236: 43.51