HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: CD2AP (Q9Y5K6)
CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)
Gene: CD2AP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	12672817
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1, PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0045296 - cadherin binding GO:0051015 - actin filament binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 639
+	Hs
		338817 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		208970 EGFR_HUMAN (1-1210): 0: 1241: 100.00		NCK2_HUMAN (2-361): 2.2e-59: 205: 16.17
+	Hs
		275158 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GRAP2_HUMAN (2-329): 1.68e-45: 166: 12.83
+	Mm
		964559 EGFR_MOUSE (1-1210): 0: 1258: 90.35		GRB2_MOUSE (112-328): 1.43e-40: 149: 18.27
+	Hs
		338251 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Rn
		924998 Q9QX70_RAT (1-1210): 0: 1241: 90.34		GRB2_RAT (112-328): 1.9e-40: 148: 18.27
+	Hs
		209056 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		NCK2_HUMAN (2-361): 2.2e-59: 205: 16.17
+	Hs
		337883 EGFR_HUMAN (1-1210): 0: 1241: 100.00		NCK1_HUMAN (113-378): 9.79e-21: 96.5: 14.24
+	Hs
		298945 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SRBS2_HUMAN (6-215): 1e-18: 92.7: 18.40
+	Mm
		964571 EGFR_MOUSE (1-1210): 0: 1258: 90.35		ARHG7_MOUSE (230-378): 9.82e-13: 73.4: 26.17
+	Hs
		208972 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		NCK2_HUMAN (2-361): 2.2e-59: 205: 16.17
+	Hs
		338419 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ARHG7_HUMAN (176-378): 4.79e-13: 74.6: 20.87
+	Hs
		339058 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ITSN2_HUMAN (1-63): 2.7e-12: 72.2: 34.92
+	Hs
		338478 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ITSN1_HUMAN (1-55): 3.97e-11: 68.8: 43.64
+	Hs
		338526 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SH319_HUMAN (75-368): 3.05e-10: 65.4: 17.45
+	Hs
		275197 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		GRAP2_HUMAN (2-329): 1.68e-45: 166: 12.83
+	Hs
		924589 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		275161 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		GRAP2_HUMAN (2-329): 1.68e-45: 166: 12.83
+	Hs
		557701 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		NCK1_HUMAN (113-378): 9.79e-21: 96.5: 14.24
+	Hs
		383587 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		NCK1_HUMAN (113-378): 9.79e-21: 96.5: 14.24